HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

penciclovir (Denavir)

Subscribe to New Research on penciclovir

structure given in first source

Also Known As:

Denavir; 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine; BRL 39123; BRL-39123; Novartis brand of penciclovir; Penciclovir Visfarm; SB-CH brand of penciclovir; Vectavir; Visfarm brand of penciclovir; penciclovir, monosodium salt; penciclovir, monosodium salt, monohydrate

Networked: 97 relevant articles (18 outcomes, 23 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Purines: 436
    - Purinones
      - Hypoxanthines: 1
        Guanine: 1530
        Acyclovir: 3596
        penciclovir: 97

Experts

1.	Gambhir, Sanjiv S: 4 articles (02/2014 - 09/2002)
2.	Aoki, Fred Y: 4 articles (07/2010 - 01/2003)
3.	De Clercq, E: 4 articles (11/2001 - 03/2000)
4.	Maggs, David J: 2 articles (01/2014 - 01/2011)
5.	Snoeck, R: 2 articles (03/2012 - 08/2000)
6.	Andrei, G: 2 articles (03/2012 - 08/2000)
7.	Hamed, Kamal: 2 articles (06/2011 - 05/2010)
8.	Vinh, Donald C: 2 articles (07/2010 - 11/2006)
9.	Lassonde, Michel: 2 articles (10/2005 - 03/2002)
10.	Martel, Alain Y: 2 articles (10/2005 - 03/2002)

Related Diseases

1.	Infection 09/01/2004 - "As a conclusion, different studies are available that have shown that it is possible to reduce viral replication and hasten lesion resolution with 1% penciclovir treatment beyond the prodromal phase of the HSV infection. " 02/01/1996 - "This study confirms the safety and potent antihepadnaviral activity of penciclovir in vivo but indicates that further improvements in antiviral therapy will be required to completely eliminate HBV infection." 08/01/1998 - "Penciclovir treatment for 12 or 24 weeks was not associated with any toxicity, establishing the efficacy and safety of long-term penciclovir therapy in chronic DHBV infection." 03/01/1988 - "Although BRL 39123 failed to eradicate the virus from mice latently infected with HSV-1, treatment initiated 5 h after infection of the ear pinna reduced the numbers of mice that developed latent infections." 03/01/1988 - "In mice infected intraperitoneally with HSV-1, BRL 39123 was 10-fold more potent than ACV and a single dose of BRL 39123 reduced virus replication within the peritoneal cavity more effectively than 3 doses of ACV given 1, 5, and 20 h after infection. "
2.	Herpes Simplex 03/01/2002 - "Effective treatment of herpes simplex labialis with penciclovir cream: combined results of two trials." 01/01/2000 - "Penciclovir cream for the treatment of sunlight-induced herpes simplex labialis: a randomized, double-blind, placebo-controlled trial. " 05/01/2001 - "Penciclovir for the treatment of herpes simplex labialis: a review." 12/01/1999 - "(1) A penciclovir skin cream has been approved in France for local treatment of herpes simplex labialis. " 08/01/1997 - "Penciclovir cream for herpes simplex labialis."
3.	Herpes Labialis (Fever Blister) 01/01/2000 - "The purpose of this study was to further define the therapeutic value of penciclovir cream in the treatment of sunlight-induced herpes labialis by comparing its efficacy and tolerability with those of an inactive control (purified water). " 01/01/2000 - "Penciclovir Cream Herpes Labialis Study Group." 04/15/2003 - "Subjects received topical penciclovir for 4 days during successive episodes of recurrent herpes labialis. " 04/15/2003 - "Susceptibility of herpes simplex virus isolates to nucleoside analogues and the proportion of nucleoside-resistant variants after repeated topical application of penciclovir to recurrent herpes labialis." 09/01/2002 - "Penciclovir susceptibilities of herpes simplex virus isolates from patients using penciclovir cream for treatment of recurrent herpes labialis."
4.	Herpes Genitalis (Genital Herpes) 09/01/2000 - "Based on these preliminary clinical findings, further evaluation of penciclovir 3% cream for topical treatment of genital herpes is planned." 10/15/2005 - "Famciclovir, the oral prodrug of penciclovir, is effective for the treatment of recurrent genital herpes. " 09/01/2000 - "To explore the potential efficacy of topical treatment of genital herpes with penciclovir cream, a randomized, double-blind, multicentre, acyclovir-controlled Phase II clinical trial of penciclovir 1% cream 5 times daily up to 7 days for suppression of genital herpes was conducted in China. " 09/01/2000 - "A total of 205 patients aged 20-59 years (mean age 36.0+/-8.8 years for acyclovir and 34.8+/-8.4 years for penciclovir) with a clinical diagnosis of genital herpes were randomly allocated to one of the 2 parallel treatment groups and used for analysis. " 09/01/2000 - "A comparison of topical application of penciclovir 1% cream with acyclovir 3% cream for treatment of genital herpes: a randomized, double-blind, multicentre trial."
5.	Keratitis 06/01/1998 - "Cidofovir and penciclovir treatments may prove to be effective against epithelial keratitis. " 08/01/2004 - "This study suggests that the efficacy of HPMPA, BVdU, and penciclovir in cats with herpesviral keratitis should be determined in vivo as their efficacy in vitro was substantially greater than that of acyclovir, already shown to have demonstrable but limited clinical antiviral activity." 06/01/1998 - "A similar degree of punctate keratitis was seen after 4 to 5 days in eyes treated with trifluridine at the highest frequency, 1% cidofovir, or penciclovir ointment. " 06/01/1998 - "To compare trifluridine eyedrops, cidofovir eyedrops, and penciclovir ophthalmic ointment for the treatment of herpes simplex virus type 1 keratitis. "

Related Drugs and Biologics

1.	Acyclovir (Aciclovir)
2.	famciclovir (Famvir)
3.	cidofovir (Vistide)
4.	valacyclovir (valaciclovir)
5.	Ganciclovir (Cytovene)
6.	Lamivudine (3TC)
7.	adefovir
8.	Podophyllin
9.	9- (3- hydroxy- 2- phosphonylmethoxypropyl)adenine
10.	acyclovir monophosphate

Related Therapies and Procedures

1.	Intravitreal Injections
2.	Kidney Transplantation
3.	Vitrectomy
4.	Transplantation (Transplant Recipients)
5.	Therapeutics