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cefpodoxime proxetil (Vantin)

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structure given in first source; prodrug for cefpodoxime

Also Known As:

Vantin; 1-(isopropoxycarbonyloxy)ethyl-7-(2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetamido)-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo(4,2,0)-oct-2-ene-2-carboxylate; CS 807; CS-807; Doxef; U 76252; U-76,252; cephalosporin 807

Networked: 89 relevant articles (15 outcomes, 32 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Perry, C M: 2 articles (01/2001 - 01/2001)
2.	Abdel-Wadood, Hanaa M: 1 article (09/2013)
3.	Ahmed, Sameh: 1 article (09/2013)
4.	Mohamed, Niveen A: 1 article (09/2013)
5.	Bavbek, Nuket: 1 article (04/2013)
6.	Bilgiç, Mukadder Ayse: 1 article (04/2013)
7.	Yilmaz, Hakki: 1 article (04/2013)
8.	Akçay, Ali: 1 article (04/2013)
9.	Kothadiya, Ajay: 1 article (08/2012)
10.	Mehdi, Hasan: 1 article (11/2007)

Related Diseases

1.	Infection 01/01/1994 - "In this study, we evaluated the clinical efficacy of cefpodoxime proxetil (CPDX-PR) in otorhinolaryngological infections. " 11/01/1995 - "A multi-institutional study on clinical effectiveness of cefpodoxime proxetil dry syrup in childhood infections." 08/01/1992 - "An open-label, dose-response study of cefpodoxime proxetil (CPD), an expanded-spectrum cephalosporin, was conducted with 58 males with uncomplicated Neisseria gonorrhoeae infections with single doses of 600, 400, 200, 100, or 50 mg of CPD administered orally by tablet. " 02/01/1990 - "This study suggests that cefpodoxime proxetil taken once or twice daily will be sufficient to treat urinary or systemic infections caused by susceptible pathogens." 07/01/1989 - "[Study of efficacy, safety and dosage on cefpodoxime proxetil in pediatric infections]."
2.	Pneumonia (Pneumonitis) 01/01/1991 - "In mice with experimental pneumonia, cefpodoxime proxetil caused sharp falls in K. " 04/01/1995 - "The clinical usefulness of cefpodoxime proxetil (CPDX-PR) was investigated in the treatment of pneumonia and chronic airway infections occurring in patients first visiting our outpatient clinic or those being treated at the outpatient clinic. " 11/01/2002 - "Cefditoren pivoxil versus cefpodoxime proxetil for community-acquired pneumonia: results of a multicenter, prospective, randomized, double-blind study." 01/01/2001 - "Oral linezolid 400 or 600mg twice daily was as effective as clarithromycin 250mg twice daily or cefpodoxime proxetil 200mg twice daily in the treatment of patients with uncomplicated SSTIs or community-acquired pneumonia. " 07/01/1989 - "Cefpodoxime proxetil (CPDX-PR, CS-807) was given orally to 18 children with acute bacterial infections including 10 with acute tonsillitis, 3 with acute bronchitis, 1 with pneumonia, 3 with staphylococcal scalded skin syndrome and 1 with infectious impetigo. "
3.	Pharyngitis (Sore Throat) 04/01/1995 - "Pharyngitis/tonsillitis: European and United States experience with cefpodoxime proxetil." 01/01/1994 - "Thus, the shorter duration of therapy, in conjunction with demonstrated clinical and bacteriological efficacy that is equivalent to standard therapy, makes cefpodoxime proxetil an acceptable alternative for the treatment of GABHS pharyngitis/tonsillitis." 09/01/1991 - "It is concluded that cefpodoxime proxetil is as effective and safe as penicillin V potassium in the treatment of pharyngitis due to S pyogenes." 04/01/1993 - "This multicenter, randomized, parallel treatment, observer-blinded study was designed to evaluate the safety and efficacy of cefpodoxime proxetil (5 mg/kg twice daily for 10 days) compared with penicillin V (13.4 mg/kg three times daily for 10 days) for treatment of Group A streptococcal pharyngitis and tonsillitis in pediatric patients. " 01/01/1994 - "A total of 220 adults and children > 10 years old (mean 29.5 +/- 11.7 years) with pharyngitis/tonsillitis were randomized to receive either cefpodoxime proxetil 100 mg bid for 5 days (n = 113) or phenoxymethyl penicillin, 600 mg tid for 10 days (n = 107). "
4.	Respiratory Tract Infections (Respiratory Tract Infection) 07/01/1992 - "Cefpodoxime proxetil may be worthy of further study in clinical trials in patients with respiratory infections." 10/01/1988 - "[Clinical studies of cefpodoxime proxetil in respiratory tract infections]." 11/01/1995 - "Once-a-day therapy of cefpodoxime proxetil for respiratory tract infections." 04/01/1995 - "The oral extended spectrum cephalosporin cefpodoxime proxetil is highly active against the bacterial pathogens commonly associated with childhood lower respiratory tract infections. " 01/01/1991 - "Six randomised comparative studies in patients with lower respiratory tract infections, 5 of which were large (enrollment of more than 200 patients) and double-blind, examined the efficacy and safety of cefpodoxime proxetil. "
5.	Tonsillitis 12/01/1990 - "The tonsillar tissue concentration after 12 h was less than 0.06 mg/kg. As the MIC for Streptococcus pyogenes is less than 0.06 mg/l, cefpodoxime proxetil may be of value in acute tonsillitis." 04/01/1995 - "Pharyngitis/tonsillitis: European and United States experience with cefpodoxime proxetil." 01/01/1994 - "Thus, the shorter duration of therapy, in conjunction with demonstrated clinical and bacteriological efficacy that is equivalent to standard therapy, makes cefpodoxime proxetil an acceptable alternative for the treatment of GABHS pharyngitis/tonsillitis." 04/01/1993 - "This multicenter, randomized, parallel treatment, observer-blinded study was designed to evaluate the safety and efficacy of cefpodoxime proxetil (5 mg/kg twice daily for 10 days) compared with penicillin V (13.4 mg/kg three times daily for 10 days) for treatment of Group A streptococcal pharyngitis and tonsillitis in pediatric patients. " 08/01/2012 - "A multicentric, open label, randomised, postmarketing efficacy study comparing multidose of lincomycin hydrochloride capsule 500 mg with multidose cefpodoxime proxetil tablet 200 mg in patients with tonsillitis, sinusitis."

Related Drugs and Biologics

1.	Penicillin V (Phenoxymethylpenicillin)
2.	Cefaclor (Ceclor)
3.	Cefixime (Suprax)
4.	cefdinir (CFDN)
5.	cefditoren pivoxil (Spectracef)
6.	CS 834
7.	cefteram pivoxil
8.	cefpodoxime
9.	Amoxicillin (Wymox)
10.	Amoxicillin-Potassium Clavulanate Combination (Co-amoxiclav)

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Anesthesia
3.	Oral Administration