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2,4-dihydroxyphenylalanine
RN given refers to (DL)- isomer
Also Known As:
2,4-DOPA; 2,4-dihydroxyphenylalanine, (L)-isomer
Networked:
3
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Catecholamines: 15682
Dihydroxyphenylalanine: 1494
2,4-dihydroxyphenylalanine: 3
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Phenols: 677
Catechols: 121
Catecholamines: 15682
Dihydroxyphenylalanine: 1494
2,4-dihydroxyphenylalanine: 3
Amino Acids, Peptides, and Proteins: 1
Amino Acids: 30675
Cyclic Amino Acids: 3
Aromatic Amino Acids: 467
Tyrosine: 10509
Dihydroxyphenylalanine: 1494
2,4-dihydroxyphenylalanine: 3
Phenylalanine: 4090
Dihydroxyphenylalanine: 1494
2,4-dihydroxyphenylalanine: 3
Related Diseases
1.
Melanoma (Melanoma, Malignant)
05/01/1985 - "
2,4-Dihydroxyphenylalanine proved to be cytotoxic to both B-16 and Cloudman melanoma cells in vitro.
"
05/01/1985 - "
In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against malignant melanoma cells.
"
05/01/1985 - "
These results show that 2,4-dihydroxyphenylalanine is toxic to melanoma cells and that activation of 2,4-dihydroxyphenylalanine requires the presence of tyrosinase.
"
04/29/1987 - "
Since 2,4-DOPA is a potential pro-drug for melanoma chemotherapy, further evaluation of its neurobiologic properties is needed.
"
05/01/1985 - "
We have evaluated the chemotherapeutic potential of 2,4-dihydroxyphenylalanine, a targeted prodrug that can be hydroxylated by tyrosinase (monophenol monooxygenase, EC 1.14.18.1) within melanoma cells to form the cellular toxin 2,4,5-trihydroxyphenylalanine (6-hydroxydopa).
"
Related Drugs and Biologics
1.
Prodrugs
2.
Monophenol Monooxygenase (Tyrosinase)
3.
6-hydroxydopa
4.
Amino Acids
Related Therapies and Procedures
1.
Drug Therapy (Chemotherapy)