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SK&F 95018

structure given in first source

Also Known As:

SK&F-95108; SKF 95018

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridazines: 11
    - SK&F 95018: 3

Related Diseases

1.	Hypertension (High Blood Pressure) 10/01/1987 - "Vasodilatation and beta-adrenoceptor antagonism have been demonstrated in the same molecule (SK & F 95018) in a combination which would be suitable for effective treatment of hypertension."
2.	Hemolysis 05/01/1988 - "Electron microscopy indicated that SK&F 95018 induced alterations in the red cell membrane which led to shape change, characterized by discocyte to spherocyte transformation, and finally haemolysis. " 05/01/1988 - "The haemolysis was shown to be related to the structure of the compound itself rather than to its pharmacological effects and development of SK&F 95018 as an antihypertensive agent was abandoned. " 01/01/1989 - "Evolution of structural changes leading to haemolysis in human erythrocytes treated with SK&F 95018, an antihypertensive compound with combined vasodilator and beta-adrenoceptor antagonist properties." 01/01/1989 - "SK&F 95018 is an antihypertensive compound with combined vasodilator and beta-adrenoceptor antagonist properties, which, when given to dogs by intravenous infusion, rapidly produced symptoms of intravascular haemolysis. "
3.	Ganglion Cysts (Ganglion) 10/01/1987 - "Over a similar dose range SK & F 95018 inhibited isoprenaline-induced tachycardia in ganglion-blocked, anaesthetized cats. "
4.	Tachycardia (Tachyarrhythmias) 10/01/1987 - "Over a similar dose range SK & F 95018 inhibited isoprenaline-induced tachycardia in ganglion-blocked, anaesthetized cats. "

Related Drugs and Biologics

1.	Adrenergic Receptors (Adrenergic Receptor)
2.	Antihypertensive Agents (Antihypertensives)
3.	Vasodilator Agents (Vasodilators)
4.	Isoproterenol (Isoprenaline)
5.	Adrenergic beta-Antagonists (beta-Adrenergic Blocking Agents)

Related Therapies and Procedures

1.	Intravenous Infusions