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handelin

Chinese drug isolated from flowers of Chrysanthemum indicum L.; structure given in first source

Also Known As:

ye ju-hua; yejuhua lactone

Networked: 6 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - handelin: 6

Experts

1.	Gao, Qian: 1 article (01/2022)
2.	Huang, Tian-E: 1 article (01/2022)
3.	Lan, Xinqiang: 1 article (01/2022)
4.	Nie, Wenhui: 1 article (01/2022)
5.	Qin, Jiawei: 1 article (01/2022)
6.	Su, Weiting: 1 article (01/2022)
7.	Sun, Sujiao: 1 article (01/2022)
8.	Wang, Qi-Quan: 1 article (01/2022)
9.	Xiang, Yang: 1 article (01/2022)
10.	Xiao, Wan-Li: 1 article (01/2022)

Related Diseases

1.	Muscular Atrophy (Muscle Atrophy) 11/27/2023 - "This study aimed to further evaluate the protective effects and molecular mechanisms of handelin in a mouse muscle atrophy model induced by cachexia and aging. " 11/27/2023 - "Lipopolysaccharide (LPS)-treated 8-week-old model mice and 23-month-old (aged) mice were used to examine the therapeutic effects of handelin on cachexia- and aging-induced muscle atrophy, respectively, in vivo. "
2.	Cachexia 11/27/2023 - "This study aimed to further evaluate the protective effects and molecular mechanisms of handelin in a mouse muscle atrophy model induced by cachexia and aging. " 11/27/2023 - "Handelin alleviates cachexia- and aging-induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation." 11/27/2023 - "Handelin ameliorated cachexia- and aging-induced skeletal muscle atrophy in vitro and in vivo, by maintaining homeostasis of protein synthesis and degradation, possibly by inhibiting inflammation. " 11/27/2023 - "Lipopolysaccharide (LPS)-treated 8-week-old model mice and 23-month-old (aged) mice were used to examine the therapeutic effects of handelin on cachexia- and aging-induced muscle atrophy, respectively, in vivo. "
3.	Body Weight (Weight, Body) 11/27/2023 - "In LPS-treated mice, handelin increased body weight (P < 0.05), the weight (P < 0.01) and cross-sectional area (CSA) of the soleus muscle (P < 0.0001) and improved motor function (P < 0.05). "
4.	Inflammation (Inflammations) 09/01/2017 - "Mechanism study reveals Cys306 modification by handelin induces an allosteric regulation to facilitate adenosine triphosphate hydrolysis capacity of Hsp70, which leads to the effective blockage of subsequent inflammation signaling pathway. " 11/27/2023 - "Handelin alleviates cachexia- and aging-induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation." 04/01/2019 - "Ye-ju-hua recorded in the Chinese Pharmacopoeia, has been widely used in China as an important heat-clearing and detoxifying herb for the treatment of inflammation, headache, and vertigo. " 11/27/2023 - "Handelin ameliorated cachexia- and aging-induced skeletal muscle atrophy in vitro and in vivo, by maintaining homeostasis of protein synthesis and degradation, possibly by inhibiting inflammation. "
5.	Sarcopenia 01/01/2022 - "Further study on mammal animal model of natural aging or sarcopenia will verify the potential clinical value of handelin."

Related Drugs and Biologics

1.	Adenosine Triphosphate (ATP)
2.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
3.	Therapeutic Uses
4.	Transcription Factor AP-1 (Transcription Factor AP 1)
5.	Messenger RNA (mRNA)
6.	Proteins (Proteins, Gene)
7.	Pancreatic Elastase (Elastase)
8.	Lipopolysaccharides
9.	Insulin-Like Peptides