HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

ML 23

melatonin antagonist

Also Known As:

ML-23; N-(3,5-dinitrophenyl)-5-methoxytryptamine; 1H-Indole-3-ethanamine, N-(3,5-dinitrophenyl)-5-methoxy-

Networked: 28 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Biogenic Amines: 992
    - Biogenic Monoamines: 29
      - Tryptamines: 1679
        Serotonin: 21125
        5-Methoxytryptamine: 78
        ML 23: 28
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Tryptamines: 1679
        Serotonin: 21125
        5-Methoxytryptamine: 78
        ML 23: 28

Experts

1.	Willis, Gregory L: 3 articles (09/2005 - 11/2004)
2.	Robertson, Alan D: 2 articles (01/2005 - 11/2004)
3.	Murugesan, Gnanabalan: 1 article (11/2021)
4.	Paranjyothi, Sugapriya: 1 article (11/2021)
5.	Prasad, Hemchand Krishna: 1 article (11/2021)
6.	Sankaran, Anupama: 1 article (11/2021)
7.	Shanmughasundaram, R: 1 article (11/2021)
8.	Venugopalan, Lakshmi: 1 article (11/2021)
9.	Befon, Angeliki: 1 article (01/2020)
10.	Chardalia, Vasiliki: 1 article (01/2020)

Related Diseases

1.	MPTP Poisoning 01/01/2005 - "On all parameters, ML-23 produced a significant remission from MPTP-induced Parkinsonism, and this effect did not abate when ML-23 treatment was withdrawn. "
2.	Asthma (Bronchial Asthma) 05/01/2003 - "In patients with asthma, FEV1 improved by 618 ml (26%) and 482 ml (25%), FIV1 by 553 ml (41%) and 475 ml (23%). "
3.	Neoplasms (Cancer) 06/01/2018 - "New compound 1 and known 9 showed potential cytotoxic activities with IC50 values of 15.327 μg/mL, 23.066 μg/mL against MCF-8 cell lines, compound1 showed noteworthy cytotoxic activity with IC50 13.033 μg/mL against A549 cancer cell line. " 12/01/2017 - "The median height was 168 cm (115-183 cm), the median weight was 65 kg (20-105 kg) and the median tumor volume was 142 ml (23-2 493 ml). " 05/01/2014 - "Of the small tumors (< 10 mL), 23 of the 35 patients had PET segmented volume outside 50% of the pathologic volume, and among the large tumors (≥ 10 mL) three of the 17 patients had PET segmented volumes that were outside 50% of pathologic volume. " 04/01/2005 - "521 patients (81%) had a PSA less than 4 ng/ml, 23 had a suspicious DRE and PSA less than 4 ng/ml. No cancer was detected by prostatic biopsies. "
4.	Parkinson Disease (Parkinson's Disease) 09/01/2005 - "The role of ML-23 and other melatonin analogues in the treatment and management of Parkinson's disease." 01/01/2005 - "From these preliminary results, it is concluded that ML-23 and other melatonin analogues have an important role to play in the treatment and clinical management of Parkinson's disease." 01/01/2005 - "Recovery from experimental Parkinson's disease in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride treated marmoset with the melatonin analogue ML-23." 11/01/2004 - "Recovery of experimental Parkinson's disease with the melatonin analogues ML-23 and S-20928 in a chronic, bilateral 6-OHDA model: a new mechanism involving antagonism of the melatonin receptor."
5.	Lymphoma (Lymphomas) 01/01/2019 - "Patients aged between 34 and 84 years, female to male ratio was 1.27:1. The final diagnoses were: small cell MALT-type ML (23 patients), large cell B-lymphoma (5 patients), diffuse malignant lymphoma (5 patients), T-cell lymphoma (1 female patient). " 10/01/2013 - "We retrospectively compared the results of PBSC collection using G-CSF alone in 11 patients with malignant lymphoma (ML), 23 patients with plasma cell neoplasms (PCN) and 48 healthy donors. "

Related Drugs and Biologics

1.	Melatonin
2.	ML 7
3.	Syndecan-1 (Syndecan 1)
4.	Osteoprotegerin
5.	Melatonin Receptors (Melatonin Receptor)
6.	Galectin 3 (LGALS3)
7.	Oxidopamine (6 Hydroxydopamine)
8.	Interleukin-8 (Interleukin 8)
9.	Granulocyte Colony-Stimulating Factor (G-CSF)
10.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)

Related Therapies and Procedures

1.	Hysterectomy