adducin

membrane-skeleton associated calmodulin-binding protein of erythrocytes; major substrate for Ca+- & phospholipid-dependent protein kinase C; alpha-beta heterodimer with subunits of MW 103kDa (alpha) & 97kDa (beta); human erythrocyte GenBank X58199; alternatively spliced human transcript GenBank U43959

Also Known As:

Networked: 223 relevant articles (4 outcomes, 55 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bianchi, Giuseppe: 34 articles (11/2014 - 02/2002)
2.	Ferrari, Patrizia: 17 articles (11/2014 - 12/2002)
3.	Manunta, Paolo: 15 articles (12/2015 - 03/2003)
4.	Ferrandi, Mara: 11 articles (11/2014 - 12/2002)
5.	Staessen, Jan A: 11 articles (01/2011 - 08/2002)
6.	Citterio, Lorena: 10 articles (12/2015 - 12/2002)
7.	Lanzani, Chiara: 9 articles (12/2015 - 03/2003)
8.	Cusi, Daniele: 9 articles (11/2010 - 02/2002)
9.	Barlassina, Cristina: 9 articles (02/2010 - 02/2002)
10.	Bianchi, G: 9 articles (05/2007 - 06/2000)

Related Diseases

1.	Hypertension (High Blood Pressure) 01/01/2005 - "It is concluded that this compound could be useful for the treatment of those forms of essential hypertension in which renal Na handling alterations and cardiac complications are associated with either increased EO levels and/or adducin polymorphism." 05/01/2007 - "An example of a prospective efficacy of pharmacogenetics and pharmacogenomics is the detection and impact of adducin polymorphisms on hypertension. " 04/01/2006 - "An example of a prospective efficacy of pharmacogenetic and pharmacogenomics is the detection and impact of adducin polymorphism on hypertension. " 02/01/2014 - "The present study was carried out to examine a possible association between α-adducin gene G614T mutation and essential hypertension in Chinese population. " 01/01/2013 - "The goal of our study is to investigate the contribution of promoter DNA methylation of α-adducin (ADD1) gene to the risk of essential hypertension (EH). "
2.	Stroke (Strokes) 06/01/2008 - "The findings in this prospective study in a population based cohort of Dutch women strongly suggest that presence of the alpha-adducin Gly460Trp polymorphism increases the risk of stroke. " 06/01/2008 - "Alpha-adducin Gly460Trp variant increases the risk of stroke in hypertensive Dutch women." 04/03/2002 - "In carriers of the adducin variant, diuretic therapy was associated with a lower risk of combined MI or stroke than other antihypertensive therapies. " 04/03/2002 - "The point estimates of the diuretic-adducin interaction were similar in separate analyses of MI (SI, 0.41; 95% CI, 0.21-0.80) and stroke (SI, 0.53; 95% CI, 0.24-1.19). " 04/03/2002 - "Among the 385 carriers of the adducin variant allele, diuretic therapy was associated with a lower risk of the combined outcome of MI and stroke than other antihypertensive therapies (OR, 0.49; 95% CI, 0.32-0.77). "
3.	Myocardial Infarction 02/01/2000 - "Association of the alpha-adducin polymorphism with blood pressure and risk of myocardial infarction." 02/01/2000 - "In men in this study, the alpha-adducin polymorphism was not associated with the risk of myocardial infarction either among those with or among those without a clinical history of hypertension. " 01/01/2009 - "The aim of the study was to determine whether the alpha-adducin 460Trp variant allele modifies the risk-lowering effect of diuretics on myocardial infarction (MI). " 01/01/2009 - "Interaction between the Gly460Trp alpha-adducin gene variant and diuretics on the risk of myocardial infarction." 04/03/2002 - "Diuretic therapy, the alpha-adducin gene variant, and the risk of myocardial infarction or stroke in persons with treated hypertension."
4.	Atherosclerosis 12/01/2006 - "Alpha-adducin polymorphism, atherosclerosis, and cardiovascular and cerebrovascular risk." 04/01/2001 - "For this reason, we sought to examine the association between the alpha-adducin (ADD1) G/W460 and G-protein beta3 subunit (GNbeta3) 825C/T polymorphisms and subclinical and clinical stroke in the Atherosclerosis Risk in Communities (ARIC) Study. " 05/01/2013 - "Hypertension is closely linked to ischaemic stroke (IS) and atherosclerosis, but there are no studies correlating the candidate hypertensive gene, namely angiotensin converting enzyme (ACE) and adducin 1 (ADD1) with magnetic resonance angiographic (MRA) abnormality, therefore this study was undertaken. " 06/01/2002 - "For this reason, we examined the association between the alpha-adducin (ADD1) G460W and G-protein beta3 subunit (GNB3) 825C>T polymorphisms and the prevalence of peripheral arterial disease (PAD) and incidence of coronary heart disease (CHD) in non-Hispanic whites from the Atherosclerosis Risk in Communities (ARIC) Study. "
5.	Genetic Predisposition to Disease (Genetic Predisposition) 01/01/2010 - "Linkage and association studies suggested the relationship between alpha-adducin polymorphism (Gly460Trp; rs4961) and genetic susceptibility to salt-sensitivity. " 03/01/1998 - "The present study brought up an important issue concerning the pathophysiological role of alpha-adducin in non-Caucasian populations, given the likely ethnic variation in the nature of genetic susceptibility loci. " 01/01/2010 - "Association between alpha-adducin gene polymorphism (Gly460Trp) and genetic predisposition to salt sensitivity: a meta-analysis." 04/01/2008 - "The alpha-adducin gene TT and ACE II genotypes might be genetic susceptibility factors to hypertension accompanying renal injury." 12/01/1997 - "Further investigation of larger and different population samples in order to assess the role of adducin gene polymorphism as a marker of genetic predisposition to the development of hypertension is warranted."

Related Drugs and Biologics

1.	17- (3- furyl)- 5beta- androstane- 3,14,17- triol
2.	Sodium
3.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
4.	Angiotensinogen
5.	Renin
6.	G-protein beta3 subunit
7.	Ouabain (G Strophanthin)
8.	Adenosine Triphosphatases (ATPase)
9.	Diuretics
10.	GTP-Binding Proteins (G-Protein)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)