(asparaginyl- alanyl- asparaginyl- proline)3

12-amino acid synthetic peptide derived from the repeating amino acid sequence found in the surface circumsporozoite protein of Plasmodium falciparum sporozoites; consists of 3 repeating units of Asn-Ala-Asn-Pro

Also Known As:

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Calvo-Calle, J Mauricio: 1 article (02/2008)
2.	Edelman, Robert: 1 article (02/2008)
3.	Gregson, Aric L: 1 article (02/2008)
4.	Nardin, Elizabeth: 1 article (02/2008)
5.	Oliveira, Giane: 1 article (02/2008)
6.	Othoro, Caroline: 1 article (02/2008)
7.	Thorton, George B: 1 article (02/2008)
8.	Jakubowski, Andrzej: 1 article (01/2007)
9.	Lomnicka, Magdalena: 1 article (01/2007)

Related Diseases

1.	Malaria 01/01/1988 - "However, the trend towards increasing susceptibility to clinical malaria in subjects entering the transmission season with lower levels of anti-(NANP)3 antibodies was modest, and combined cross-sectional and longitudinal data indicated that the humoral response to (NANP)3 did not play a major role in the development of immunity to clinical malaria in the population we studied." 01/01/1988 - "A conserved repeated epitope, (NANP)3, of the circumsporozoite protein of Plasmodium falciparum has been identified previously as a putative target for artificially induced immunity to malaria. " 01/01/1989 - "A comparative study of three enzyme-linked immunosorbent assays (ELISAs) that employed different (NANP)n peptides (the synthetic peptides (NANP)3 and (NANP)40 as well as the recombinant peptides R32tet32 and R32LR) was carried out using serum samples from individuals who were living in different malaria-endemic areas. " 02/15/1993 - "We have characterized the immune response of mice to multiple Ag peptide systems (MAP) containing the immunodominant B cell epitope (NANP)3 and one of three distinct Th epitopes, Th2R, Th3R, and CS.T3, of the C terminal region of the circumsporozoite protein of Plasmodium falciparum, a human malaria parasite. " 10/23/1986 - "falciparum sporozoites in humans living in malaria-endemic areas was measured using as antigen the synthetic peptide (NANP)3, which represents the immunodominant region of the circumsporozoite (CS) protein. "
2.	Falciparum Malaria (Plasmodium falciparum Malaria) 04/29/1993 - "falciparum malaria vaccine candidate consisting of tetanus toxoid coupled to linear (Asn-Ala-Asn-Pro)3 ((NANP)3). "
3.	Reperfusion Injury 05/01/1991 - "Experiments were carried out to provide evidence of the effect of L-arginine (L-Arg), its analogue NG-monomethyl-L-arginine (MeArg) and of some nitrovasodilators (sodium nitroprusside, NaNP; 3-morpholino-sydnonimine, SIN-1) which spontaneously release nitric oxide (NO) on ischemia-reperfusion injury, histamine release and mast cell degranulation, occurring after multiple ligature and release of the left anterior descending (LAD) coronary artery in isolated perfused guinea-pig hearts. "
4.	Ischemia 01/01/2007 - "To analyze the functional integrity of smooth muscle cells and endothelium, one-minute intracoronary infusions of endothelium-independent (sodium nitroprusside, NaNP; 3 micromol L(-1)) and endothelium-dependent (substance P, SP; 10 nmol L(-1)) vasodilators were used before ischemia and at the reperfusion time. "
5.	Hepatitis 02/06/2008 - "ICC-1132 (Malariavax) is a recombinant, virus-like particle malaria vaccine comprised of hepatitis core antigen engineered to express the central repeat regions from Plasmodium falciparum circumsporozoite protein containing an immunodominant B [(NANP)(3)] epitope, an HLA-restricted CD4 (NANPNVDPNANP) epitope and a universal T cell epitope (T*) (amino acids 326-345, NF54 isolate). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Peptides (Polypeptides)
3.	Epitopes
4.	Antibodies
5.	Immunoglobulin M (IgM)
6.	Immunoglobulin G (IgG)
7.	Antigens
8.	Immunodominant Epitopes
9.	Nitroprusside (Sodium Nitroprusside)
10.	(asparaginyl- alanyl- asparaginyl- proline)3

Related Therapies and Procedures

1.	Ligation