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bis(1,3-dibutylbarbiturate)trimethine oxonol

fluorescent probe for membrane potentials

Also Known As:

DiBaC4; bis(1,3-dibutylbarbituric acid)trimethyne oxonol; di-BA-C4; diBA-C4

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Isoxazoles: 155
      - bis(1,3-dibutylbarbiturate)trimethine oxonol: 8
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Barbiturates: 1074
        bis(1,3-dibutylbarbiturate)trimethine oxonol: 8

Experts

1.	Clementi, Emily A: 1 article (02/2014)
2.	Håkansson, Anders P: 1 article (02/2014)
3.	Marks, Laura R: 1 article (02/2014)
4.	Roche-Håkansson, Hazeline: 1 article (02/2014)
5.	Auzmendi, Jerónimo A: 1 article (01/2013)
6.	Bañuelos-Cabrera, Ivette: 1 article (01/2013)
7.	Calixto González, Eduardo: 1 article (01/2013)
8.	González-Trujano, María Eva: 1 article (01/2013)
9.	Lazarowski, Alberto: 1 article (01/2013)
10.	Orozco-Suárez, Sandra: 1 article (01/2013)

Related Diseases

1.	Hypoxia (Hypoxemia) 04/01/2005 - "Hypoxia causes membrane depolarization in human CD3+ T cells, as measured by fluorescence-activated cell sorting (FACS) with the voltage-sensitive dye DiBAC4(3). " 04/01/1994 - "We used microfluorimetry on subconfluent monolayers of PASMC in primary culture loaded with either a membrane potential-sensitive dye, bis(1,3-dibutylbarbituric acid) trimethine oxonol (DiBAC4; DPASMC), to estimate membrane potential, or the Ca(2+)-sensitive fluorophore, fura 2, to measure [Ca2+]i. Hypoxia increased fluorescence from PASMC loaded with DiBAC4, consistent with membrane depolarization. "
2.	Starvation 12/01/1997 - "coli and Salmonella starvation measured by DiBAC4(3) incorporation (flow cytometry and CSLM) was found to be in concordance with respiratory activity as detected by a tetrazolium salt (CTC) reduction." 12/01/1997 - "coli and Salmonella viability and starvation by confocal laser microscopy and flow cytometry using rhodamine 123, DiBAC4(3), propidium iodide, and CTC."
3.	Hemorrhagic Shock 04/01/2006 - "The ASMCs isolated from normal rats and those with severe hemorrhagic shock were labeled with DiBAC4 (3) for membrane potential detection. "
4.	Seizures (Absence Seizure) 01/01/2013 - "Rats with repetitive PTZ-induced seizures demonstrated lower phenytoin-induced anticonvulsant effects, increased number of DiBAC4(3) fluorescence cells and P-gp overexpression in hippocampus and neocortex, as well as augmentation of the induced fEPSP in CA1 field. "
5.	Rupture 02/17/2014 - "We developed protocols using the bis-oxonol dye DiBAC4(3) and the cell-impermeant dye propidium iodide to measure membrane depolarization and rupture, respectively, as well as methods to optimally load the pneumococci with the AM esters of the ratiometric dyes Fura-2, PBFI, and BCECF to detect changes in intracellular concentrations of Ca(2+), K(+), and H(+), respectively, using a fluorescence-detection plate reader. "

Related Drugs and Biologics

1.	Coloring Agents (Dyes)
2.	Fura-2 (Fura 2)
3.	Propidium (Propidium Iodide)
4.	Rhodamine 123
5.	Tetrazolium Salts
6.	Messenger RNA (mRNA)
7.	Phenytoin (Dilantin)
8.	Fluorescent Dyes (Fluorescent Probes)
9.	Esters
10.	Anticonvulsants (Antiepileptic Drugs)

Related Therapies and Procedures

1.	Lasers (Laser)