gambogic acid

08/09/2022 - "This study elucidates the mechanism of action of gambogic acid from the perspective of metabolic reprogramming regulation in cancer cells."
10/01/2018 - "Gambogic acid (GA) possesses good anti-tumor efficacy in preclinical studies, however, its poor hydrophilicity, short blood circulation time and side effect limited its clinical application. "
01/01/2016 - "Gambogic acid (GA), the major active ingredient of gamboge, has been approved by the Chinese Food and Drug Administration for clinical trials in cancer patients due to its strong anticancer activity. "
11/01/2015 - "The present study aimed to investigate the anti-tumor mechanisms of gambogic acid (GA) on NCI-H1993 xenografts in vivo. "
09/01/2013 - "The anti-cancer activity of gambogic acid has been tested in in vitro and in vivo studies. "

01/01/2012 - "The aim of the current study was to evaluate the efficacy of a drug delivery system utilizing gambogic acid-loaded magnetic Fe(3)O(4) nanoparticles (GA-MNP-Fe(3)O(4)) on the suppression of ETS1-mediated cell proliferation and migration in Panc-1 pancreatic cancer cells. "
01/01/2011 - "Study of the enhanced anticancer efficacy of gambogic acid on Capan-1 pancreatic cancer cells when mediated via magnetic Fe3O4 nanoparticles."
01/01/2019 - "Our previous study suggested that gambogic acid might be involved in autophagy; however, its role in pancreatic cancer remained unclear. "
01/01/2018 - "Additionally, a whole-genome transcription profiling study was performed in order to identify possible candidate players modulating the antitumor effect of gambogic acid on pancreatic cancer cells. "
01/01/2019 - "The inhibition of autophagy promotes the cytotoxicity of gambogic acid by increasing the accumulation of ROS in pancreatic cancer cells. "

12/01/2008 - "The present study investigated the antiinvasive and antimetastatic action of gambogic acid (GA) in MDA-MB-435 human breast carcinoma cells. "
09/01/2018 - "Gambogic acid sensitizes breast cancer cells to TRAIL-induced apoptosis by promoting the crosstalk of extrinsic and intrinsic apoptotic signalings."
12/01/2012 - "Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells."
12/01/2009 - "Gambogic acid induced human breast cancer cells MCF-7 apoptosis by reducing bcl-2 expression via p53."
10/01/2008 - "Anti-invasive effect of gambogic acid in MDA-MB-231 human breast carcinoma cells."

06/01/2012 - "Enhancement of anticancer efficacy of chemotherapeutics by gambogic acid against gastric cancer cells."
12/01/2023 - "MiR-1275 Targeting SPARC Promotes Gambogic Acid-Induced Inhibition of Gastric Cancer."
01/01/2023 - "Gambogic Acid Inhibits Gastric Cancer Cell Proliferation through Necroptosis."
04/01/2021 - "Critical role of miR-26a-5p/Wnt5a signaling in gambogic acid-induced inhibition of gastric cancer."
06/28/2005 - "Anticancer effect and apoptosis induction of gambogic acid in human gastric cancer line BGC-823."

10/01/2013 - "We previously demonstrated that gambogic acid (GA) is a promising chemotherapeutic compound for human osteosarcoma treatment. "
01/01/2013 - "Gambogic acid (GA), the natural product, has been demonstrated to be a promising chemotherapeutic drug for osteosarcoma (OS) due to its ability to induce apoptosis and cell cycle arrest. "
05/01/2011 - "Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest."
10/01/2016 - "Nanomedicine-based combination of gambogic acid and retinoic acid chlorochalcone for enhanced anticancer efficacy in osteosarcoma."
10/01/2013 - "Viability inhibition effect of gambogic acid combined with cisplatin on osteosarcoma cells via mitochondria-independent apoptotic pathway."