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ICI 142269
RN given refers to (Z)-isomer; structure given in first source
Also Known As:
ICI-142269; tamoxifen metabolite Y; tamoxifen-ol
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Benzylidene Compounds: 10
Stilbenes: 657
Tamoxifen: 14288
ICI 142269: 2
Related Diseases
1.
Breast Neoplasms (Breast Cancer)
03/01/1983 - "
A new hydroxylated metabolite of tamoxifen, Metabolite Y [trans-1-(p-beta-hydroxyethoxyphenyl)-1,2-diphenylbut-1-ene] was characterized and subsequently measured by high-performance liquid chromatography in serum from patients receiving normal (10 mg twice daily) and high dose (greater than or equal to 150 mg twice daily) tamoxifen therapy for treatment of advanced breast cancer.
"
2.
Astrocytoma (Pilocytic Astrocytoma)
05/13/1994 - "
Tamoxifen, 4-hydroxytamoxifen, N-desdimethyltamoxifen, N-desmethyltamoxifen and tamoxifen-ol are eluted in that order at a flow-rate of 1.0 ml/min. The method has been validated for use in a clinical study utilizing tamoxifen in the treatment of recurrent cerebral astrocytomas.
"
Related Drugs and Biologics
1.
Tamoxifen
2.
desdimethyltamoxifen
3.
N-desmethyltamoxifen
4.
afimoxifene (hydroxytamoxifen)
Related Therapies and Procedures
1.
Therapeutics