4-nitroimidazole

10/01/2020 - "Recent studies reveal 5-nitroimidazole refractory infection occurs in up to 50% of cases. "
05/10/2023 - "However, 5-nitroimidazole resistance has been increasingly recognized and may occur in up to 10% of infections. "
06/01/2012 - "Actually, the infection treatment is based on 5-nitroimidazole drugs. "
01/01/2009 - "vaginalis infections are treated with a 5-nitroimidazole derivate. "
08/01/2007 - "Metronidazole, a 5-nitroimidazole drug, has been the gold standard for several decades in the treatment of infections with microaerophilic protist parasites, including Entamoeba histolytica. "

08/12/2008 - "[Efficacy of 5-nitroimidazole derivatives in treatment of bacterial vaginosis]."
08/12/2008 - "To evaluate the efficacy and adverse effects of 5-nitroimidazole derivatives in treatment of bacterial vaginosis (BV). "
01/01/2013 - "[Efficacy of combined 5-nitroimidazole and probiotic therapy of bacterial vaginosis: randomized open trial]."
01/01/2013 - "The application of Gynophilus after conventional 5-nitroimidazole treatment for bacterial vaginosis increased the clinical and microbiological efficacy of the therapy by 25% - 30%. "
01/01/2018 - "Secnidazole is a next-generation 5-nitroimidazole approved for more than three decades in Europe, Asia, South America and Africa and recently in the USA as a single-dose (2 g) treatment of bacterial vaginosis (BV). "

08/01/2020 - "5-Nitroimidazole refractory giardiasis was common, indicating that an alternative first-line treatment may be needed. "
03/01/2019 - "Efficacy of 5-nitroimidazole compounds for giardiasis in Cuban children: systematic review and meta-analysis."
12/31/2022 - "Antimicrobial drugs, particularly 5-nitroimidazole (5-NIs), are used to treat giardiasis in humans. "
04/01/2008 - "Although 5-nitroimidazole compounds have formed the mainstay of giardiasis treatment for several years, the increasing number of reports of refractory cases given these and other antigiardial agents has raised concern and led to a search for other compounds. "
12/01/2018 - "Standard treatment for giardiasis is commonly with 5-nitroimidazole (5-NI) compounds, or nitazoxanide; however, some individuals experience treatment failure. "

12/21/2010 - "Here it is shown that fexinidazole, a 2-substituted 5-nitroimidazole rediscovered by the Drugs for Neglected Diseases initiative (DNDi) after extensive compound mining efforts of more than 700 new and existing nitroheterocycles, could be a short-course, safe and effective oral treatment curing both acute and chronic HAT and that could be implemented at the primary health care level. "
09/01/2012 - "Fexinidazole, a 2-substituted 5-nitroimidazole rediscovered by the Drugs for Neglected Diseases initiative (DNDi) after extensive compound mining of public and pharmaceutical company databases, has the potential to become a short-course, safe and effective oral treatment, curing both acute and chronic HAT. "
01/01/2012 - "Fexinidazole, a 2-subsituted 5-nitroimidazole drug candidate rediscovered following extensive compound mining by the Drugs for Neglected Diseases initiative and currently in Phase I clinical study for the treatment of human African trypanosomiasis, was evaluated in experimental models of acute and chronic CD caused by different strains of Trypanosoma cruzi. "

01/01/2011 - "The aim of this study is to investigate the effectiveness of short-term, combined 5-nitroimidazole treatment in vaginal dysbacteriosis with dominant anaerobic species. "
01/01/2011 - "[Short - term combined 5-nitroimidazole treatment in vaginal dysbacteriosis with dominant anaerobic species]."
01/01/2011 - "Based on the results mentioned above it was determined that the short-term combined 5-nitroimidazole therapy was effective in treatment of vaginal dysbacteriosis with dominant anaerobic species."