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CGS 12066B
RN given for ((Z)-2-butenedioate (1:2))-salt (CGS 12066B); CGS 12066A is the (ethanedioate (1:2))-salt; structure given in first source
Also Known As:
7-trifluoromethyl-4-(4-methyl-1-piperazinyl)pyrrolol(1,2-a)quinoxaline; CGS 12066; CGS 12066A; CGS 12066B ethanedioate (1:2); CGS-12066A; CGS-12066B; Pyrrolo(1,2-a)quinoxaline, 4-(4-methyl-1-piperazinyl)-7-(trifluoromethyl)-, (Z)-2-butenedioate (1:2)
Networked:
7
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinoxalines: 324
CGS 12066B: 7
Experts
1.
García, Mónica
: 1 article (11/2007)
2.
Martín, M Luisa
: 1 article (11/2007)
3.
Morán, Asunción
: 1 article (11/2007)
4.
Ortizde Urbina, A Vega
: 1 article (11/2007)
5.
San Román, Luis
: 1 article (11/2007)
Related Diseases
1.
Hypothermia
11/01/1990 - "
The mixed 5-HT1A/1B-agonist CGS 12066B at 10 mg kg-1 potentiated hypothermia and had no effect on hypoactivity.
"
10/01/1996 - "
Hypothermia and the 5-HT syndrome induced by CGS 12066B independently of 5-HT(1B) receptor activation.
"
2.
Bradycardia
11/01/2007 - "
4. Vagally induced bradycardia in diabetic rats was not affected by administration of the selective 5-HT(2) receptor agonist alpha-methyl-5-HT (150 microg/kg), the selective 5-HT(3) receptor agonist 1-phenylbiguanide (150 microg/kg) or the selective 5-HT(1B) receptor agonist CGS-12066B (50 microg/kg).
"
01/01/1993 - "
The intrathecal (i.th., T8-10) administration in conscious rats of the 5-hydroxytryptamine (5-HT)1A agonist 8-OH-DPAT (10 nmol), and to a lesser extent the 5-HT1B agonist CGS 12066B (6 nmol), resulted in a blood pressure reduction and a bradycardia.
"
3.
Pain (Aches)
01/01/1991 - "
CGS 12066B (0.5-10.0 mg/kg) and MK-212 (0.3-10.0 mg/kg), selective agonists for 5-HT1B and 5-HT1C sites, respectively, failed to influence this particular form of adaptive pain inhibition.
"
4.
Hyperalgesia
01/01/1992 - "
No hyperalgesia was seen after 5-HT1B, CGS-12066B maleate and m-trifluoromethylphenyl-piperazine hydrochloride; 5-HT2+IC, alpha methyl 5HT and (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl; or 5-HT3, 2-methyl-5-hydroxytryptamine maleate and phenylbiguanide, agonists.
"
5.
Body Weight (Weight, Body)
10/01/1997 - "
There were no behavioral effects of systemic CGS-12066A (4 mg/kg body weight) on female hamsters.
"
Related Drugs and Biologics
1.
5-HT1B Serotonin Receptor
2.
Serotonin (5 Hydroxytryptamine)
3.
phenyl biguanide
4.
Serotonin 5-HT1 Receptor Agonists
5.
8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)
6.
Dihydrotachysterol (AT 10)
7.
Piperazine
8.
2-methyl-5-HT
9.
alpha-methylserotonin
10.
maleic acid (maleate)