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3- (3- pyridinyl)- 1H,3H- pyrrolo(1,2- c)thiazole- 7- carboxamide
platelet activating factor antagonist
Also Known As:
48740 RP; 48740RP; RP 48740; RP 55778; RP 55779; RP-48740; RP-55778; RP-55779
Networked:
8
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Thiazoles: 392
3-(3-pyridinyl)-1H,3H-pyrrolo(1,2-c)thiazole-7-carboxamide: 8
Pyridines: 88
3-(3-pyridinyl)-1H,3H-pyrrolo(1,2-c)thiazole-7-carboxamide: 8
Organic Chemicals: 133
Sulfur Compounds: 278
Thiazoles: 392
3-(3-pyridinyl)-1H,3H-pyrrolo(1,2-c)thiazole-7-carboxamide: 8
Related Diseases
1.
HIV Infections (HIV Infection)
03/15/1993 - "
This study suggests that RP 55778 may represent potentially useful compounds in the treatment of HIV infection.
"
05/01/1994 - "
Pretreatment of MDM with a TNF alpha synthesis inhibitor, RP 55778, 4 h prior to HIV infection induced a modified cytokine pattern during the first ten hours of infection: TNF alpha production was totally inhibited despite comparable amounts of IL6.
"
2.
Infections
06/01/1994 - "
Infection of human macrophages with an endogenous tumour necrosis factor-alpha (TNF-alpha)-independent human immunodeficiency virus type 1 isolate is unresponsive to the TNF-alpha synthesis inhibitor RP 55778.
"
05/01/1994 - "
Pretreatment of MDM with a TNF alpha synthesis inhibitor, RP 55778, 4 h prior to HIV infection induced a modified cytokine pattern during the first ten hours of infection: TNF alpha production was totally inhibited despite comparable amounts of IL6.
"
3.
Endotoxemia
11/01/1989 - "
These results indicate that PAF and TNF can mediate the functional manifestations associated with endotoxemia and only RP 55778 appears to show potential for activity against an already established LPS response.
"
4.
Thrombosis (Thrombus)
01/01/1989 - "
N 48740 RP, a pyrrolo(1,2-c)thiazole derivative and platelet-activating factor inhibitor, was tested in a thrombosis model, in which thrombi are produced in small rat mesenteric vessels.
"
5.
Thrombocytopenia (Thrombopenia)
04/27/1988 - "
The pretreatment with the specific PAF-acether receptor antagonist, BN 52021 (2.5-15 mg/kg), 48740 RP (6-25 mg/kg) and WEB 2086 (0.25-1 mg/kg) blocked the thrombocytopenia dose dependently.
"
Related Drugs and Biologics
1.
Platelet Activating Factor
2.
Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.
WEB 2086 (apafant)
4.
ginkgolide B
5.
Cytokines
6.
Interleukin-6 (Interleukin 6)
7.
Endotoxins