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peimisine

isolated from Fritillaria ussuriensis

Also Known As:

peimissine

Networked: 6 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - peimisine: 6

Experts

1.	Gao, Xu: 1 article (01/2022)
2.	Jin, Xin: 1 article (01/2022)
3.	Lan, Meng: 1 article (01/2022)
4.	Li, Chun-Nan: 1 article (01/2022)
5.	Sun, Jia-Ming: 1 article (01/2022)
6.	Zhang, Hui: 1 article (01/2022)
7.	Guo, Dong-Qin: 1 article (06/2019)
8.	Mu, Mao-Jun: 1 article (06/2019)
9.	Yang, Min: 1 article (06/2019)
10.	Zhang, Di-Gui: 1 article (06/2019)

Related Diseases

1.	Dysbiosis 11/25/2023 - "Peimisine ameliorates DSS-induced colitis by suppressing Jak-Stat activation and alleviating gut microbiota dysbiosis in mice."
2.	Colitis 11/25/2023 - "In this research, the protective effects of peimisine on colitis mice were investigated. " 11/25/2023 - "Peimisine ameliorates DSS-induced colitis by suppressing Jak-Stat activation and alleviating gut microbiota dysbiosis in mice." 11/25/2023 - "Peimisine can ameliorate colitis by inhibiting Jak-Stat signaling pathway, reversing gut microbiota alterations, suppressing macrophage M1 polarization, maintaining the Th17/Treg cell balance, and reducing sustained inflammatory cytokines-related inflammatory injury."
3.	Inflammation (Inflammations) 01/01/2022 - "Study the mechanism of peimisine derivatives on NF-κB inflammation pathway on mice with acute lung injury induced by lipopolysaccharide." 07/01/2015 - "And the results of network analysis showed that dongbeinine, verticinone-N-oxide, verticine N-oxide, peimine, peiminine, isobaimonidine, dongbeirine, peimisine and simi-arenol which with high degree acted on xanthine dehydrogenase/oxidase, matrix metalloproteinase-9, an arachidonate 5-lipoxygenase-activating protein, tyrosine-protein kinase and etc. Inhibition of these targets can prevent the formation of uric acid, reduce inflammation by uric acid and regulate the body's immune response. "
4.	Acute Lung Injury 01/01/2022 - "Peimisine is one of the alkaloids in Fritillariae ussuriensis Bulbus, which has anti-acute lung injury effect. " 01/01/2022 - "Study the mechanism of peimisine derivatives on NF-κB inflammation pathway on mice with acute lung injury induced by lipopolysaccharide."
5.	Pneumonia (Pneumonitis) 02/26/2023 - "Network pharmacology indicated that FTB may act on the TNF signaling pathway, HIF-1 signaling pathway, JAK-STAT signaling pathway, etc. The results demonstrated that imperialine (P8), peimisine (P9), peiminine (P11), ebeiedine (P15), zhebeirine (P16), and puqiedine (P18) may be potential Q-markers of FTB, and AKT1, IL-6, VEGFA, TP53, EGFR, STAT3, PPARG, MMP9, and CASP3 may be promising therapeutic targets for pneumonia treatment that are worthy of further research." 02/26/2023 - "A total of 26 compounds in FTB were identified by UPLC-QTOF-MS. Ten of these compounds were screened as Q-markers based on network pharmacology for their anti-pneumonia effects, including imperialine, peimisine, peiminine, ebeiedinone, zhebeirine, puqiedine, 9-hydroxy-10,12-octadecadienoic acid, (9Z,12Z,15Z)-13-hydroxy-9,12,15-octadecatrienoic acid, 9,12,15-octadecatrienoic acid, and (2E,4Z,7Z,10Z,13Z,16Z,19Z)-2,4,7,10,13,16,19-docosaheptaenoic acid methyl ester (DAME). "

Related Drugs and Biologics

1.	Lipopolysaccharides
2.	Alkaloids
3.	peiminine
4.	5-Lipoxygenase-Activating Proteins
5.	Caspase 3 (Caspase-3)
6.	Matrix Metalloproteinase 9 (Gelatinase B)
7.	Cytokines
8.	Interleukin-6 (Interleukin 6)
9.	Xanthine Dehydrogenase
10.	Uric Acid (Urate)