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SK&F 75670

RN refers to HBr; N-methyl derivative of SK&F 38393

Also Known As:

SK&F-75670; SKF 75670

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - SK&F 75670: 4

Related Diseases

1.	Dyskinesias (Dyskinesia) 12/01/1992 - "SKF 38393 and SKF 75670 (partial D1 agonists) also induced some oral dyskinesia, but to a lesser extent than SKF 81297, and with few licking movements. "
2.	Parkinson Disease (Parkinson's Disease) 02/01/1995 - "The effects of co-administration of quinpirole with benzazepine D1 dopamine (DA) agonists possessing full/supramaximal (SKF 80723 and SKF 82958), partial (SKF 38393 and SKF 75670) and no efficacies (SKF 83959) in stimulating adenylate cyclase (AC) were investigated in rodent and primate models of Parkinson's disease (PD). "
3.	Hypothermia 11/21/1989 - "The selective D-2 receptor agonists, quinpirole and LY 163502, and the mixed D-1/D-2 agonist, apomorphine, induced a dose-dependent hypothermia, whereas the selective D-1 receptor agonists, SK&F 81297, SK&F 38393 and SK&F 75670, induced hyperthermia. "
4.	Catalepsy 08/01/1994 - "R-SKF 38393 (R(+)-7,8- dihydroxy-1-phenyl-2,3,4,5-tetrahydro-[1H]-3-benzazepine) and SKF 75670 (7,8-dihydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-[1H]-3- benzazepine), which are considered partial dopamine D1 receptor agonists, also consistently produced dose-related increases in catalepsy-associated behavior and had effects comparable in magnitude to those of dopamine D1 receptor antagonists. "

Related Drugs and Biologics

1.	2,3,4,5- Tetrahydro- 7,8- dihydroxy- 1- phenyl- 1H- 3- benzazepine (SKF 38393)
2.	Quinpirole
3.	SK&F 81297
4.	Dopamine D1 Receptors (Dopamine D1 Receptor)
5.	Dopamine (Intropin)
6.	Apomorphine
7.	Adenylyl Cyclases (Adenylyl Cyclase)
8.	SK&F 82958 (SKF 82958)
9.	quinelorane

Related Therapies and Procedures

1.	Induced Hyperthermia (Thermotherapy)