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topiramate (Topamax)

a hypoglycemic agent; RN & structure given in first source; RN not in Chemline 6/87

Also Known As:

Topamax; 2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate; Cilag brand of topiramate; Epitomax; Janssen brand of topiramate; McN 4853; McN-4853; Ortho brand of topiramate

Networked: 2120 relevant articles (456 outcomes, 602 trials/studies)

Relationship Network

Drug Context: Research Results

Carbohydrates: 4088
- Monosaccharides: 152
  - Hexoses: 107
    - Fructose: 2828
      - topiramate: 2120
  - Ketoses: 4
    - Fructose: 2828
      - topiramate: 2120

Experts

1.	Luszczki, Jarogniew J: 21 articles (02/2016 - 05/2003)
2.	Silberstein, Stephen D: 17 articles (08/2015 - 01/2002)
3.	Czuczwar, Stanislaw J: 16 articles (11/2013 - 05/2003)
4.	McElroy, Susan L: 15 articles (12/2015 - 01/2003)
5.	Marson, Anthony G: 15 articles (08/2015 - 01/2007)
6.	Hulihan, Joseph: 13 articles (01/2011 - 06/2003)
7.	Diener, Hans-Christoph: 12 articles (02/2015 - 08/2004)
8.	Keck, Paul E: 9 articles (12/2015 - 02/2003)
9.	Goadsby, P J: 9 articles (11/2014 - 04/2002)
10.	Ford, Lisa: 9 articles (07/2014 - 03/2009)

Related Diseases

1.	Migraine Disorders (Migraine) 09/01/2014 - "Topiramate is highly effective in migraine prophylaxis but clinicians using the drug need to be aware of the potential for bothersome or serious adverse events. " 01/01/2013 - "Triptan was effective for a migraine headache, but it was ineffective for attacks of SUNA, while topiramate dramatically reduced the SUNA attacks. " 02/01/2010 - "Topiramate is a highly effective drug in migraine prophylaxis and is considered a first-line treatment. " 09/15/2008 - "Topiramate has been shown to be highly effective for preventive treatment of migraine and its use has been significantly increased in the last few years. " 01/01/2013 - "More studies designed specifically to compare the efficacy or safety of topiramate versus other interventions with proven efficacy in the prophylaxis of migraine are needed."
2.	Seizures (Seizure) 01/01/2005 - "The results confirmed the earlier data received by the authors that topamax was most effective in generalized convulsive, partial and secondary generalized seizures. " 10/01/1997 - "Topiramate is highly effective in the control of previously therapy-resistant partial seizures, with or without secondary generalization. " 01/01/2002 - "The preliminary findings of this study suggest that topiramate is very effective against tonic-clonic seizures in alcohol withdrawal syndrome. " 01/01/2013 - "After the initiation of topiramate therapy both cases responded with marked decrease in myoclonic seizure frequency and improvement of quality of life. " 06/01/2011 - "Prospective studies evaluating the safety and efficacy of topiramate for both seizures and neuroprotection will be important in determining whether it deserves widespread use in clinical practice."
3.	Epilepsy (Aura) 01/01/2003 - "The efficacy of topamax was shown in all types of epilepsy and in most types of epileptic seizures. " 05/01/2003 - "Significant improvement in frontal lobe associated neuropsychological functions after withdrawal of topiramate in epilepsy patients." 07/01/2007 - "In terms of remission, Topamax was more effective in adolescents, youths and adults than in younger children, and this pattern was also seen in the treatment of symptomatic epilepsy. " 10/01/2006 - "With its established efficacy for epilepsy treatment and its increased use for other disorders, topiramate-positive findings are more common in death-investigation and human-performance casework. " 09/01/2012 - "We therefore studied the efficacy and safety of topiramate (TPM), which is a drug that is indicated to be effective for intractable childhood epilepsy, for ES. "
4.	Weight Loss (Weight Reduction) 01/01/2014 - "Compared to placebo, there was a significantly greater weight loss with topiramate in all analyses: 9.5 kg (SE 1.17) in the complete case analysis (N = 86), 6.8 kg (SE 0.66) using LOCF (N = 561), 6.4 kg (SE 0.90) using MI (N = 561) and 1.5 kg (SE 0.28) using BOCF (N = 561). " 02/01/2007 - "Topiramate treatment produced significantly greater weight loss than placebo and the majority of this loss was explained by a decrease in body fat stores. " 11/01/2004 - "Significantly greater weight loss was observed in the topiramate-treated group than in those treated with placebo (difference in weight loss between the 2 groups: 2.3 kg [5.1 lb] [3.2%]; 95% CI = 1.3% to 4.4%, p < .01). " 07/01/2014 - "This pilot open-label study examined the efficacy of topiramate in weight loss and the trajectory of weight changes after topiramate discontinuation. " 04/01/2013 - "Topiramate induced weight loss and improved glycemic control in obese, diabetic patients."
5.	Bipolar Disorder (Mania) 05/01/2001 - "These preliminary results suggest that topiramate may be a useful therapy for bipolar disorders, with promising results even in the most treatment-refractory patients." 05/01/2005 - "The results of our study indicate that topiramate does not possess a pharmacological property that three drugs with proven efficacy in treating bipolar disorder have in common." 04/01/2002 - "Topiramate is reported to be effective in acute mania and rapid-cycling bipolar disorder in several open studies, but methodological problems in a double-blind study led to a failed study in acute mania. " 10/01/2001 - "However, once the antidepressant-associated manias (28 of the sample, of 97 subjects) were excluded from the controlled study, the post-hoc analyses indicated the higher dose (512 mg/day) topiramate treatment group showed a statistically significant reduction in endpoint Y-MRS change scores as compared to placebo (p < 0.03). " 10/01/2001 - "More definitive controlled data on the efficacy of topiramate in the acute and continuation phases as well as for the prophylaxis either as monotherapy or as combination treatment of bipolar disorder are ongoing, and the results are awaited."

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3.	gabapentin (Neurontin)
4.	Anticonvulsants (Antiepileptic Drugs)
5.	Carbamazepine (Tegretol)
6.	zonisamide (Zonegran)
7.	etiracetam (levetiracetam)
8.	Phentermine (Adipex-P)
9.	oxcarbazepine (Trileptal)
10.	tiagabine (Gabitril)

Related Therapies and Procedures

1.	Vagus Nerve Stimulation
2.	Relaxation Therapy
3.	Psychology Biofeedback (Biofeedback)
4.	Drug Therapy (Chemotherapy)
5.	Ketogenic Diet