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alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase

Subscribe to New Research on alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase

Also Known As:

Glc-N-Ac-transferase V; GnT V enzyme; Mgat5 protein, mouse; N-acetylglucosaminyltransferase V; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase V; UDP-GLCNAC-alpha-mannoside beta(1,6)N-acetylglucosaminyltransferase; UDP-N-acetylglucosamine alpha-6-D-mannoside beta1,6 N-acetylglucosaminyltransferase V; alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase; beta 1-6 GlcNAc transferase V

Networked: 85 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Transferases: 4296
    - Glycosyltransferases: 242
      - N-Acetylhexosaminyltransferases
        N-Acetylglucosaminyltransferases: 20
        alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase: 85

Experts

1.	Miyoshi, Eiji: 22 articles (08/2015 - 01/2004)
2.	Taniguchi, Naoyuki: 12 articles (07/2011 - 01/2004)
3.	Kim, Yong-Sam: 7 articles (02/2013 - 01/2008)
4.	Yoo, Jong Shin: 5 articles (09/2012 - 01/2008)
5.	Ko, Jeong-Heon: 4 articles (02/2013 - 01/2008)
6.	Guo, Hua-Bei: 4 articles (12/2009 - 12/2002)
7.	Pierce, Michael: 4 articles (12/2009 - 12/2002)
8.	Kondo, Akihiro: 4 articles (10/2006 - 05/2005)
9.	Nakagawa, Takatoshi: 4 articles (10/2006 - 05/2005)
10.	Terao, Mika: 3 articles (08/2015 - 07/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2011 - "Accumulating evidence indicate that N-acetylglucosaminyltransferase V (Mgat5 or GnT-V) is involved in cancer development. " 01/01/2010 - "N-acetylglucosaminyltransferase V (GnT-V) has been reported to be positively associated with tumor progression, but its mechanism still remains unknown. " 11/01/2009 - "High expression of N-acetylglucosaminyltransferase V in mucinous tumors of the ovary." 06/01/2009 - "N-acetylglucosaminyltransferase-V (GnT-V) has been reported to be closely associated with tumor migration, but the mechanism has been not currently clear. " 11/28/2008 - "In some cancer cells, an increase of beta1,6-GlcNAc catalyzed by N-acetylglucosaminyltransferase V (GnT-V) is related to the promotion of cancer cell motility. "
2.	Carcinoma (Carcinomatosis) 08/05/1999 - "Expression of N-acetylglucosaminyltransferase V in gastric carcinomas was significantly enhanced compared to normal tissue. " 10/25/1996 - "Transcriptional regulation of the N-acetylglucosaminyltransferase V gene in human bile duct carcinoma cells (HuCC-T1) is mediated by Ets-1." 04/01/2014 - "Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder." 01/01/2005 - "Expression of N-acetylglucosaminyltransferase V in the development of human esophageal cancers: immunohistochemical data from carcinomas and nearby noncancerous lesions." 07/27/2007 - "To study in detail the mechanisms by which aberrant N-glycosylation caused by altered N-acetylglucosaminyltransferase V(GnT-V, GnT-Va, and Mgat5a) expression can regulate the invasiveness-related phenotypes found in some carcinomas, we utilized specific small interfering RNA (siRNA) to selectively knock down GnT-V expression in the highly metastatic and invasive human breast carcinoma cell line, MDA-MB231. "
3.	Prostatic Neoplasms (Prostate Cancer) 08/29/2014 - "The purpose of this study was to investigate the relationship between N-acetylglucosaminyltransferase V (GnT-V) and radiation sensitivity of prostate cancer (PCa) cells both in vitro and in vivo. " 08/29/2014 - "Inhibition of N-acetylglucosaminyltransferase V enhances sensitivity of radiotherapy in human prostate cancer." 06/01/2010 - "To investigate the effect of short hairpin RNA (shRNA) targeting N-acetylglucosaminyltransferase V (GnT-V) on the proliferation of prostate cancer PC-3 cells. " 06/01/2010 - "[Short hairpin RNA targeting N-acetylglucosaminyltransferase V inhibits the proliferation of prostate cancer PC-3 cell line]." 07/01/2008 - "Evaluating the function of matriptase and N-acetylglucosaminyltransferase V in prostate cancer metastasis."
4.	Colonic Neoplasms (Colon Cancer) 01/01/2004 - "Attachment of human colon cancer cells to vascular endothelium is enhanced by N-acetylglucosaminyltransferase V." 01/01/2004 - "Expression of N-acetylglucosaminyltransferase V (GnT-V) in colon cancer has been shown to be related to hematogenous metastasis and poor prognosis. " 01/01/2008 - "Functional proteomics study reveals that N-Acetylglucosaminyltransferase V reinforces the invasive/metastatic potential of colon cancer through aberrant glycosylation on tissue inhibitor of metalloproteinase-1." 06/01/2010 - "For this, aberrant glycoforms of the tissue inhibitor of metalloproteinase 1 (TIMP1) and protein tyrosine phosphatase kappa (PTPkappa), previously known target proteins for N-acetylglucosaminyltransferase-V (GnT-V), were enriched by phytohemagglutinin-L(4) (L-PHA) lectin and comparatively analyzed in the conditioned medium of the WiDr colon cancer cell line and its GnT-V-overexpressing transfectant cells. "
5.	Astrocytoma (Pilocytic Astrocytoma) 01/01/2015 - "In this study, we investigated the clinicopathological significance of N-linked β1-6-GlcNAc branches and GnT-V enzyme in the development and progression of astrocytic glioma. "

Related Drugs and Biologics

1.	Tissue Inhibitor of Metalloproteinase-1
2.	Small Interfering RNA (siRNA)
3.	Complementary DNA (cDNA)
4.	Carbohydrates
5.	Polysaccharides
6.	Oligosaccharides
7.	Acetylglucosamine
8.	Asparagine
9.	Proteins (Proteins, Gene)
10.	Antigens

Related Therapies and Procedures

1.	Radiotherapy