Haemophilus influenzae type b-polysaccharide vaccine-diphtheria toxoid conjugate

the type b capsular polysaccharide of HIB-vaccine is chemically combined with the diphtheria toxoid
Also Known As:
Dpo 20 vaccine; Haemophilus influenzae b oligosaccharide vaccine-diphtheria toxoid conjugate; Hib-PS-DT vaccine; Hib-PS-diphtheria toxoid conjugate vaccine; PRP-D; Prohibit
Networked: 67 relevant articles (1 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Jeffrey, Martin: 21 articles (06/2015 - 04/2003)
2. Jeffrey, M: 16 articles (01/2015 - 01/2002)
3. González, L: 16 articles (01/2015 - 01/2002)
4. González, Lorenzo: 13 articles (11/2012 - 05/2003)
5. Martin, S: 11 articles (01/2015 - 01/2002)
6. Martin, Stuart: 9 articles (11/2012 - 05/2003)
7. McGovern, Gillian: 8 articles (06/2015 - 01/2007)
8. Sisó, S: 6 articles (04/2013 - 03/2006)
9. Thurston, L: 4 articles (01/2015 - 08/2012)
10. Hunter, N: 4 articles (06/2009 - 01/2002)

Related Diseases

1. Infection
2. Scrapie
3. Bovine Spongiform Encephalopathy (Mad Cow Disease)
06/01/2009 - "This study characterizes the traumatic brain lesions associated with the I/C injection of the bovine spongiform encephalopathy agent in sheep, assesses the relevance of such lesions in the outcome of clinical disease and provides insight into the mechanisms of PrP(d) conversion and amplification following I/C challenge. "
06/01/2009 - "To determine the nature of subcellular changes and their association with PrP(d) we perfusion-fixed brains of eight bovine spongiform encephalopathy (BSE)-affected cows and three control cattle for immunogold electron microscopy at two different neuroanatomical sites. "
11/01/2012 - "To address this discrepancy, 11 brain samples of sheep affected with natural scrapie or experimental bovine spongiform encephalopathy were selected on the basis of the magnitude and predominant types of PrP(d) accumulation, as shown by immunohistochemical (IHC) examination; contra-lateral hemi-brain samples were inoculated at three different dilutions into transgenic mice overexpressing ovine PrP and were also subjected to quantitative analysis by three biochemical tests (BCTs). "
02/01/2006 - "Immunohistochemical epitope mapping of abnormal PrP accumulations (PrP(d)) in brain can help in characterizing sheep TSE sources or strains and in identifying potential bovine spongiform encephalopathy (BSE) infections of sheep. "
03/01/2005 - "It has previously been reported that disease-associated prion protein (PrP(d)) derived from natural scrapie and from sheep infected experimentally with bovine spongiform encephalopathy (BSE) differed in respect of their immunohistochemical and immunoblotting properties. "
4. Poliomyelitis (Polio)
5. Diphtheria
09/13/1993 - "The aim of this study was to examine the immunogenicity of a Haemophilus influenzae type b (Hib) vaccine (PRP-D) in Danish children younger than 18 months of age, given at the same time as a diphtheria-, tetanus- and polio-vaccine at the age of five, six and 15 months. "
09/01/1987 - "Haemophilus influenzae vaccine containing polyribosyl ribitol phosphate (PRP) or PRP covalently linked to diphtheria toxoid (PRP-D) was given to 94 healthy infants 17 to 22 months of age at the same time, but not at the same site, as a diphtheria-tetanus-pertussis booster. "
01/01/1992 - "A randomized, controlled comparison was made in 175 healthy 18-month-old children given either diphtheria and tetanus toxoids and pertussis vaccine, adsorbed (DTP) and haemophilus b diphtheria toxoid conjugate vaccine (PRP/D) concurrently at separate sites (66 children) or a new vaccine combining these products (109 children). "
02/01/1992 - "Mean antibody levels after three injections of polyribosylribitol phosphate conjugated with mutant diphtheria protein (PRP-CRM) or polyribosylribitol phosphate conjugated with tetanus toxoid (PRP-T) were 3.08 micrograms/ml and 3.64 micrograms/ml, respectively, significantly higher than those after the use of polyribosylribitol phosphate conjugated with outer-membrane protein of Neisseria meningitidis (PRP-OMP) (1.14 micrograms/ml) or polyribosylribitol phosphate conjugated with diphtheria toxoid (PRP-D) (0.28 microgram/ml). "
11/01/1993 - "The concept of conjugating carbohydrate with a carrier protein increasing immunogenicity of the PRP led to 4 PRP--protein conjugate vaccines: PRP-diphtheria toxoid conjugated vaccine (PRP-D), outer-membrane protein of Neisseria meningitidis conjugated (PRP-OMP), cross-reacting mutant diphtheria protein (PRP-HbOC) and tetanus-Toxoid conjugated vaccine (PRP-T). "

Related Drugs and Biologics

1. Antibodies
2. PrPSc Proteins
3. Codon (Codons)
4. Threonine (L-Threonine)
5. Methionine (L-Methionine)
6. Haemophilus influenzae type b polysaccharide vaccine (HIB-vaccine)
7. Diphtheria Toxoid (Vaccine, Diphtheria)
8. Conjugate Vaccines
9. Vaccines
10. Tetanus Toxoid (Vaccine, Tetanus)

Related Therapies and Procedures

1. Oral Administration
2. Lymph Node Excision (Lymph Node Dissection)
3. Injections