calcium-dependent protein kinase

MW 51,000; requires Ca; not stimulated by calmodulin, phospholipids or diacylglycerol; phosphorylates casein & histones forming primarily phosphoserine & phosphothreonine, respectively

Also Known As:

Networked: 66 relevant articles (6 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Van Voorhis, Wesley C: 11 articles (12/2021 - 10/2013)
2.	Ojo, Kayode K: 11 articles (01/2021 - 10/2013)
3.	Choi, Ryan: 10 articles (12/2021 - 03/2014)
4.	Maly, Dustin J: 10 articles (01/2021 - 10/2013)
5.	Hulverson, Matthew A: 9 articles (12/2021 - 01/2016)
6.	Barrett, Lynn K: 8 articles (01/2021 - 01/2016)
7.	Fan, Erkang: 7 articles (01/2019 - 10/2013)
8.	Whitman, Grant R: 6 articles (12/2021 - 01/2017)
9.	Vidadala, Rama S R: 5 articles (01/2021 - 10/2013)
10.	Huang, Wenlin: 4 articles (01/2019 - 01/2016)

Related Diseases

1.	Toxoplasmosis 12/01/2021 - "The Neospora caninum Calcium-dependent protein kinase 1 (NcCDPK1) inhibitor BKI-1294 had demonstrated excellent efficacy in a pregnant mouse model of neosporosis, and was also highly efficacious in a pregnant sheep model of toxoplasmosis. " 10/27/2023 - "The calcium-dependent protein kinase 1 (CDPK1) inhibitor BKI-1748 has shown a promising safety profile for its use in humans and a good efficacy against Toxoplasma gondii infection in vitro and in mouse models. " 11/01/2020 - "Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis." 11/01/2019 - "One of the most advanced and promising therapeutic targets, demonstrating potential to treat both acute and chronic toxoplasmosis, is the calcium-dependent protein kinase 1 (CDPK1) which plays an essential role in the intracellular replicative cycle of the parasite, and has no direct mammalian homolog. " 06/01/2007 - "We report here the isolation of a new calcium-dependent protein kinase gene from the human toxoplasmosis parasite, Toxoplasma gondii. "
2.	Cryptosporidiosis 01/01/2022 - "Characterization of Calcium-Dependent Protein Kinase 2A, a Potential Drug Target Against Cryptosporidiosis." 01/01/2017 - "Cryptosporidium parvum calcium-dependent protein kinase 1 (CpCDPK1) is a promising target for drug development against cryptosporidiosis. " 10/15/2013 - "A novel calcium-dependent protein kinase inhibitor as a lead compound for treating cryptosporidiosis." 01/01/2018 - "Selective inhibitors of Cryptosporidium calcium-dependent protein kinase 1 ( CpCDPK1) based on the 1 H-pyrazolo[3,4- d]pyrimidin-4-amine (pyrazolopyrimidine, PP) scaffold are effective in both in vitro and in vivo models of cryptosporidiosis. " 01/01/2021 - "Bumped kinase inhibitors (BKIs) that target Cryptosporidium parvum calcium-dependent protein kinase 1 have been well established as potential drug candidates against cryptosporidiosis. "
3.	Wounds and Injuries (Trauma) 01/01/2011 - "Here, we report studies on the effects of various phospholipids on the activity and expression of maize wound-responsive calcium-dependent protein kinase (ZmCPK11). " 01/01/2011 - "Regulation of wound-responsive calcium-dependent protein kinase from maize (ZmCPK11) by phosphatidic acid." 12/01/2005 - "A wound-responsive and phospholipid-regulated maize calcium-dependent protein kinase." 08/01/2005 - "Although protein phosphorylation is required for many early Avr9/Cf-9-signaling events, so far the only phosphorylation targets known in this race-specific signaling pathway are three kinases: the two mitogen-activated protein kinases, wound-induced protein kinase and salicylic acid-induced protein kinase, and the calcium-dependent protein kinase NtCDPK2. "
4.	Cysts 08/20/2022 - "In this study, we observed that the knockout of calcium-dependent protein kinase 3 (CDPK3) in the type II ME49 strain greatly attenuated virulence in mice and significantly reduced cyst formation. " 01/01/2017 - "gondii calcium-dependent protein kinase family, was recently identified as an essential regulator for viable cyst development in T. " 01/01/2017 - "gondii calcium-dependent protein kinase 1 inhibitor), endochin-like quinolones, miltefosine, rolipram abolish, and guanabenz can be repurposed into an effective anti-parasitic with a unique ability to reduce brain tissue cysts (88.7, 88, 78, 74, and 69%, respectively). "
5.	Carcinoma (Carcinomatosis) 04/15/1987 - "The present studies show that PKC and calcium-dependent protein kinase specific activities are reduced in human colon carcinomas when compared to their normal adjacent colon mucosa. " 04/01/1989 - "The new phospholipid analogue 3-hexadecylmercapto-2-methoxy-methyl-propyl-1-phosphocholine inhibits the phospholipid-calcium-dependent protein kinase, partially purified from Walker carcinoma cells with a Ki value of 0.56 microM. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Salts
3.	Interleukin-15 (Interleukin 15)
4.	Pyridazines
5.	Amines
6.	interleukin-21 (interleukin 21)
7.	Phospholipids (Phosphatides)
8.	Proteins (Proteins, Gene)
9.	Calcium
10.	Mitogen-Activated Protein Kinases

Related Therapies and Procedures

1.	Therapeutics
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Spinal Injections
4.	Hepatectomy
5.	Drug Therapy (Chemotherapy)