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SIPI 549
RN refers to HCl; structure given in first source
Also Known As:
4'-methyl-7-(2-hydroxy-3-isopropylaminopropoxy)flavone; SIPI-549; methylflavonolamine
Networked:
5
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrans: 130
Benzopyrans: 195
Chromones: 159
Flavonoids: 9773
Flavonols: 321
SIPI 549: 5
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzopyrans: 195
Chromones: 159
Flavonoids: 9773
Flavonols: 321
SIPI 549: 5
Related Diseases
1.
Atherosclerosis
03/01/1993 - "
Methylflavonolamine protects aorta from atherosclerosis in cholesterol-fed rabbits.
"
03/01/1993 - "
The effect of methylflavonolamine [4'-methyl-7-(2-hydroxy-3-isopropylamino-propoxy)-flavone hydrochloride, MFA], synthesized recently by the Shanghai Institute of Pharmaceutical Industry, on the development of atherosclerosis was studied in male New Zealand white rabbits fed cholesterol for 10 wk. MFA, 7 mg.kg-1 daily ip, did not significantly alter the serum total cholesterol, HDL, and triglyceride levels, but significantly lowered the aortic cholesterol and calcium contents.
"
2.
Reperfusion Injury
07/01/1995 - "
To examine the possible beneficial action of methylflavonolamine (MFA) on cerebral ischemia/reperfusion injury.
"
07/01/1995 - "
Protection of methylflavonolamine against acute cerebral ischemia reperfusion injury in rats.
"
3.
Myocardial Infarction
05/01/1993 - "
Effects of methylflavonolamine (MFA) on TXA2 and PGI2 plasma levels in rabbits of myocardial infarction were investigated.
"
05/01/1993 - "
[Effects of methylflavonolamine on TXA2 and PGI2 plasma levels in rabbits with myocardial infarction].
"
4.
Hypotension (Low Blood Pressure)
07/01/1989 - "
When SIPI-549 was administered intravenously to the intact donor dog, a slight hypotension was induced in a dose range of 0.01 to 3 mumol/kg. At the same time, slight negative chronotropic and inotropic responses appeared in isolated and perfused atria, suggesting a cardiac depressant action.
"
5.
Brain Ischemia (Cerebral Ischemia)
07/01/1995 - "
To examine the possible beneficial action of methylflavonolamine (MFA) on cerebral ischemia/reperfusion injury.
"
07/01/1995 - "
Protection of methylflavonolamine against acute cerebral ischemia reperfusion injury in rats.
"
Related Drugs and Biologics
1.
Triglycerides (Triacylglycerol)
2.
HDL Cholesterol
3.
Cholesterol
4.
Calcium
5.
Anti-Arrhythmia Agents
6.
flavone