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3',5'- dioctanoyl- 5- fluoro- 2'- deoxyuridine
lipophilic prodrug of fluorodeoxyuridine; structure given in first source
Also Known As:
5-fluoro-2'-deoxy-O',O'-dioctanoyluridine; FdUrd-C8
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrimidines: 510
Pyrimidine Nucleosides: 50
Uridine: 1186
Deoxyuridine: 331
Floxuridine: 690
3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine: 3
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Pyrimidine Nucleosides: 50
Uridine: 1186
Deoxyuridine: 331
Floxuridine: 690
3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine: 3
Deoxyribonucleosides: 34
Deoxyuridine: 331
Floxuridine: 690
3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine: 3
Related Diseases
1.
Neoplasms (Cancer)
08/01/1988 - "
Though no significant difference in the FdUrd-C8 levels among the tumor and nontumorous liver was observed immediately after administration, slower elimination of FdUrd-C8 from the tumor (t 1/2 = 15.8 h) than that from nontumorous sites (t 1/2 = 3.8-4.2 h) resulted in selective retention of FdUrd-C8 (17- to 157-fold) in the tumor.
"
04/01/1987 - "
Pathological observation also showed that FdUrd-C8 had a strong anticancer effect on VX-2 tumor growing in the liver of the rabbits.
"
08/01/1988 - "
Esterase activity, which is responsible for the regeneration of FdUrd from FdUrd-C8, was relatively low in the tumor before administration and gradually increased after administration.
"
04/01/1987 - "
Tumor growth rates in 1 week of the untreated group, a group given injections of 0.2 ml of Lipiodol alone, and groups given injections of 0.2 ml of Lipiodol containing 30, 50, 70, and 100 mg of FdUrd-C8 were 636, 436, 34.8, 14.9, -2.4, and -10.4% of the size at the time of treatment, respectively.
"
04/01/1987 - "
Selective anticancer effects of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine, a lipophilic prodrug of 5-fluoro-2'-deoxyuridine, dissolved in an oily lymphographic agent on hepatic cancer of rabbits bearing VX-2 tumor.
"
2.
Hepatocellular Carcinoma (Hepatoma)
08/01/1989 - "
[Selective anticancer effects of intra-arterial infusion of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine (TT82) in hepatocellular carcinoma].
"
08/01/1988 - "
Selective accumulation of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine (FdUrd-C8) and sustained release of its active metabolites in VX-2 rabbit hepatoma following intraarterial administration of FdUrd-C8 solution in Lipiodol.
"
08/01/1988 - "
Selective accumulation/retention of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine (FdUrd-C8) and sustained release of its active metabolites, 5-fluoro-2'-deoxyuridine (FdUrd) and 5-fluoro-2'-deoxyuridylate (FdUMP), in the rabbit hepatoma (VX-2) were achieved following intrahepatic arterial administration of FdUrd-C8 solution in Lipiodol.
"
3.
Liver Neoplasms (Liver Cancer)
04/01/1987 - "
Selective anticancer effects of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine, a lipophilic prodrug of 5-fluoro-2'-deoxyuridine, dissolved in an oily lymphographic agent on hepatic cancer of rabbits bearing VX-2 tumor.
"
04/01/1987 - "
3',5'-Dioctanoyl-5-fluoro-2'-deoxyuridine (FdUrd-C8), one of the lipophilic prodrugs of 5-fluoro-2'-deoxyuridine (FdUrd) was dissolved in an oily lymphographic agent (Lipiodol Ultra-Fluid), which had been studied as a carrier of the anticancer drug for hepatic cancer.
"
Related Drugs and Biologics
1.
Ethiodized Oil (Ethiodol)
2.
5-fluoro-2'-deoxyuridine
3.
3',5'- dioctanoyl- 5- fluoro- 2'- deoxyuridine
4.
Solutions
5.
Prodrugs
6.
Fluorodeoxyuridylate
7.
Esterases
Related Therapies and Procedures
1.
Injections
2.
Intra-Arterial Infusions