alginate-polylysine-alginate (A-PL-A)

biomembrane used to encapsulate hamster pancreatic islets; presumed structure given in first source

Also Known As:

A-PL-A; alginate-poly-L-lysine; poly-L-lysine alginate; polylysine alginate

Networked: 29 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Alginates: 3209
    - alginate-polylysine-alginate: 29
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Polylysine: 237
    - alginate-polylysine-alginate: 29
- Amino Acids: 30675
  - Basic Amino Acids: 178
    - Lysine: 6737
      - Polylysine: 237
        alginate-polylysine-alginate: 29
  - Diamino Amino Acids: 101
    - Lysine: 6737
      - Polylysine: 237
        alginate-polylysine-alginate: 29

Experts

1.	Zhang, Xulang: 3 articles (08/2012 - 07/2005)
2.	Li, Tao: 2 articles (12/2015 - 12/2011)
3.	Prakash, Satya: 2 articles (01/2014 - 01/2010)
4.	Lee, Minhyung: 2 articles (01/2013 - 02/2004)
5.	Ma, Xiaojun: 2 articles (07/2006 - 07/2005)
6.	Sambanis, Athanassios: 2 articles (07/2006 - 01/2005)
7.	Wang, Wei: 2 articles (07/2006 - 07/2005)
8.	Xie, Yubing: 2 articles (07/2006 - 07/2005)
9.	Zhang, Ying: 2 articles (07/2006 - 07/2005)
10.	Chang, Patricia L: 2 articles (04/2005 - 07/2002)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2014 - "The present study validates the success of alginate-poly-L-lysine-alginate (APA) microcapsules containing thalidomide in reducing colonic inflammation, and proposes a potential remedy for Crohn's disease. "
2.	Crohn Disease (Crohn's Disease) 01/01/2014 - "The present study validates the success of alginate-poly-L-lysine-alginate (APA) microcapsules containing thalidomide in reducing colonic inflammation, and proposes a potential remedy for Crohn's disease. "
3.	Myocardial Infarction 09/25/2021 - "Cardiosphere-derived cells (CDCs) encapsulated within alginate-poly-L-lysine-alginate (APA) microcapsules present a promising treatment alternative for myocardial infarction. "
4.	Insulinoma 05/01/2000 - "In this study we have investigated the effects of short-term hypoxic exposure (up to 24 h) on the bioenergetic status, metabolism, and insulin secretion of perfused pancreatic constructs composed of alginate/poly-L-lysine/alginate (APA) encapsulated mouse insulinoma betaTC3 cells. " 06/01/2001 - "The effects of alginate composition on the growth of murine insulinoma betaTC3 cells encapsulated in alginate/poly-L-lysine/alginate (APA) beads, and on the overall metabolic and secretory characteristics of the encapsulated cell system, were investigated for four different types of alginate. " 07/01/1997 - "Towards the development of a bioartificial pancreas: a 13C NMR study on the effects of alginate/poly-L-lysine/alginate entrapment on glucose metabolism by beta TC3 mouse insulinoma cells." 01/01/2005 - "The model substitute consisted of insulin-secreting mouse insulinoma betaTC3 cells entrapped in calcium alginate/poly-L-lysine/alginate (APA) beads. " 01/01/1999 - "In this work, we studied the effects of 3- and 4-day-long hypoxic episodes on the metabolic and secretory activities and on the levels of intracellular metabolites detectable by phosphorus-31 nuclear magnetic resonance ((31)P NMR) of alginate/poly-L-lysine/alginate entrapped betaTC3 mouse insulinomas continuously perfused with culture medium. "
5.	Pain (Aches) 12/01/2011 - "This study was to investigate the relationship of dose-effect and time-effect of Alginate-Polylysine-Alginate (APA) microencapsulated bovine chromaffin cells on the treatment of pain model rats. " 07/08/2014 - "Intrathecal injection of alginate-poly (l) lysine-alginate (APA) microencapsulated human pheochromocytoma cells leads to antinociceptive effect in a rat model of bone cancer pain, and this effect was blocked by opioid antagonist naloxone and alpha 2-adrenergic antagonist rauwolscine. "

Related Drugs and Biologics

1.	Alginates
2.	Capsules (Microcapsules)
3.	Thalidomide (Thalomid)
4.	chenodeoxycholate sulfate conjugate (CDCS)
5.	Glucose (Dextrose)
6.	Insulin (Novolin)
7.	Angiostatins
8.	Intercellular Signaling Peptides and Proteins (Growth Factors)
9.	Ethylene Glycol (Monoethylene Glycol)
10.	Interleukin-1 Receptors (Interleukin 1 Receptor)

Related Therapies and Procedures

1.	Artificial Pancreas
2.	Heterologous Transplantation (Xenotransplantation)
3.	Microspheres (Microsphere)
4.	Spinal Injections