insulin proreceptor

MW 190,000 single-chain precursor that contains exclusively asparagine-N-linked high-mannose-type carbohydrate chains

Also Known As:

insulin pro-receptors; insulin proreceptors; proreceptor, insulin

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

1.	Insulin Resistance 08/01/1992 - "We previously reported on patients with severe insulin resistance due to unprocessed insulin proreceptors. " 10/01/1989 - "Unprocessed insulin proreceptor in cultured fibroblasts from a patient with extreme insulin resistance." 06/01/1989 - "Binding specificity and intramolecular signal transmission of uncleaved insulin proreceptor in transformed lymphocytes from a patient with extreme insulin resistance." 06/16/1988 - "Insulin resistance by unprocessed insulin proreceptors point mutation at the cleavage site." 05/01/1988 - "Insulin resistance by uncleaved insulin proreceptor. "
2.	Donohue Syndrome 09/01/2003 - "Another patient with leprechaunism was homozygous for a novel Asn431Asp mutation, which only partially reduces insulin proreceptor processing and activation of signaling cascades. "