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1,2,3,7,8-pentachlorodibenzo-p-dioxin

Also Known As:

PeCDD

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Dioxins and Dioxin-like Compounds: 5
  - Dioxins: 1199
    - Polychlorinated Dibenzodioxins: 2278
      - 1,2,3,7,8-pentachlorodibenzo-p-dioxin: 6
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Polychlorinated Dibenzodioxins: 2278
      - 1,2,3,7,8-pentachlorodibenzo-p-dioxin: 6

Experts

1.	Rowlands, Craig: 1 article (03/2008)
2.	Safe, Stephen: 1 article (03/2008)
3.	Zhang, Shu: 1 article (03/2008)
4.	Aoki, Yasunobu: 1 article (07/2006)
5.	Maruyama, Wakae: 1 article (07/2006)
6.	Gao, X: 1 article (03/2000)
7.	Rozman, K K: 1 article (03/2000)
8.	Terranova, P F: 1 article (03/2000)

Related Diseases

1.	Weight Gain 03/01/2000 - "Previous studies have shown that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), and 1,2,3,4,7, 8-hexachlorodibenzo-p-dioxin (HxCDD), and their equipotent mixture block ovulation, reduce ovarian weight gain and alter preovulatory hormone levels in a similar manner. "
2.	Body Weight (Weight, Body) 12/01/1998 - "In the present study, the CDDs decreased body weight in L-E rats in the following order of potency: TCDD > PeCDD > HxCDD > HpCDD. " 12/01/1998 - "By contrast, in H/W rats HxCDD was the most effective congener in producing loss of body weight, followed by HpCDD, PeCDD and TCDD. "
3.	Hepatocellular Carcinoma (Hepatoma) 03/01/2008 - "TCDD, 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), 2,3,7,8-tetrachlorodibenzofuran (TCDF), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), and 3,3',4,4',5-pentachlorobiphenyl (PCB126) induced CYP1A1-dependent activities in HEK293 human embryonic kidney, Panc1 pancreatic cancer, and Hepa1c1c7 mouse hepatoma cell lines. " 08/01/1989 - "Treatment of rat hepatoma H-4-IIE cells in culture with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,7,8-tetrachlorodibenzofuran (TCDF), 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), 1,2,3,7,8-pentachlorodibenzofuran (PeCDF), 1,2,7,8-TCDF, and 2,3,7-trichlorodibenzo-p-dioxin (TrCDD) resulted in the structure-dependent induction of aryl hydrocarbon hydroxylase and ethoxyresorufin O-deethylase activities. "
4.	Pancreatic Neoplasms (Pancreatic Cancer) 03/01/2008 - "TCDD, 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), 2,3,7,8-tetrachlorodibenzofuran (TCDF), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), and 3,3',4,4',5-pentachlorobiphenyl (PCB126) induced CYP1A1-dependent activities in HEK293 human embryonic kidney, Panc1 pancreatic cancer, and Hepa1c1c7 mouse hepatoma cell lines. "
5.	Neoplasms (Cancer) 07/15/2006 - "To quantify the toxicity of a mixture of three dioxin congeners, we calculated the new relative potencies (REPs) for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), and 2,3,4,7,8- pentachlorodibenzofuran (PeCDF), focusing on their tumor promotion activity. "

Related Drugs and Biologics

1.	1,2,3,7,8-pentachlorodibenzo-p-dioxin
2.	Polychlorinated Dibenzodioxins (TCDD)
3.	1,2,3,6,7,8-hexachlorodibenzodioxin
4.	Hormones (Hormone)
5.	1,2,3,4,6,7,8-heptachlorodibenzodioxin
6.	2,3,7,8-tetrachlorodibenzofuran
7.	Cytochrome P-450 CYP1A1 (CYP1A1)
8.	Mixed Function Oxygenases (Monooxygenases)
9.	Hydrocarbons
10.	Dioxins