pegademase bovine (pegADA)

polyethylene glycol covalently attached to adenosine deaminase; used to stabilize the enzyme for therapy of adenosine deaminase deficiency and severe combined immunodeficiency disease

Also Known As:

Networked: 20 relevant articles (4 outcomes, 1 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Aiuti, Alessandro: 2 articles (02/2012 - 07/2007)
2.	Grunebaum, Eyal: 2 articles (10/2009 - 07/2007)
3.	Roifman, Chaim M: 2 articles (10/2009 - 07/2007)
4.	Baldo, Brian A: 1 article (02/2015)
5.	Sauer, Aisha V: 1 article (02/2012)
6.	Sanvito, Francesca: 1 article (02/2012)
7.	Gagliani, Nicola: 1 article (02/2012)
8.	Brigida, Immacolata: 1 article (02/2012)
9.	Villa, Anna: 1 article (02/2012)
10.	Scaramuzza, Samantha: 1 article (02/2012)

Related Diseases

1.	Infection 12/01/2005 - "Although replacement therapy with PEG-ADA is effective in preventing infections, immune function does not return to normal, and most patients remain lymphopenic. " 08/01/1993 - "Replacement therapy with PEG-ADA has resulted in improvement in growth, a variable increase in the number of peripheral blood lymphocytes, and a decrease in the incidence of severe infections. " 12/01/2005 - "Treatment with PEG-ADA was begun, the biochemical markers of ADA deficiency normalized, and his clinical progress was very good without significant infections. " 08/01/1988 - "Adenosine deaminase deficiency with late onset of recurrent infections: response to treatment with polyethylene glycol-modified adenosine deaminase." 01/01/2001 - "Pegademase is used in the treatment of severe combined immunodeficiency disease, pegaspargase for the treatment of various leukaemias, and pegylated interferon-alpha for chronic hepatitis C virus infections. "
2.	Priapism 09/01/2010 - "Intriguingly, in both ADA-deficient mice and SCD Tg mice with established priapism, we found that normalization of adenosine levels in penile tissues by PEG-ADA treatment relieved the heightened EFS-induced cavernosal relaxation in priapism. " 09/01/2010 - "Our studies have identified that PEG-ADA is a novel, safe, and mechanism-based drug to prevent and correct excess adenosine-mediated increased cavernosal relaxation seen in two independent priapic animal models, and suggested its therapeutic possibility in men suffering from priapism." 09/01/2010 - "We found that lowering adenosine levels in penile tissues by PEG-ADA treatment from birth in ADA-deficient mice prevented the increased EFS-induced CCS relaxation associated with priapism. "
3.	Lung Diseases (Lung Disease) 10/01/2009 - "Polyethylene glycol-modified adenosine deaminase improved lung disease but not liver disease in partial adenosine deaminase deficiency."
4.	Liver Diseases (Liver Disease) 10/01/2009 - "Polyethylene glycol-modified adenosine deaminase improved lung disease but not liver disease in partial adenosine deaminase deficiency."
5.	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 10/01/1991 - "Pegademase bovine: replacement therapy for severe combined immunodeficiency disease." 07/01/1991 - "PEG-ADA represents an important progress for the treatment of ADA deficiency associated with severe combined immunodeficiency disease." 03/01/2005 - "A four year-old boy with adenosine deaminase (ADA-) deficient severe combined immunodeficiency(SCID) receiving PEG-ADA was treated under a gene therapy protocol targeting peripheral blood lymphocytes (PBLs) in 1995. " 01/01/1995 - "PEG-ADA is a long-circulating form of adenosine deaminase (ADA) that has been in use for > 8 years as replacement therapy for severe combined immunodeficiency disease due to ADA deficiency. " 01/01/2009 - "Pegademase bovine (PEG-ADA) for the treatment of infants and children with severe combined immunodeficiency (SCID)."

Related Drugs and Biologics

1.	Adenosine
2.	Severe combined immunodeficiency due to adenosine deaminase deficiency
3.	Adenosine Deaminase
4.	Polyethylene Glycols (Polyethylene Glycol)
5.	pegademase bovine (pegADA)
6.	Collagenases (Collagenase)
7.	Interferon-alpha (Interferon Alfa)
8.	Biological Markers (Surrogate Marker)
9.	Tissue Plasminogen Activator (Alteplase)
10.	Methotrexate (Mexate)

Related Therapies and Procedures

1.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
2.	Enzyme Replacement Therapy
3.	Stem Cell Transplantation
4.	Transplants (Transplant)
5.	Injections