dehydrodolichyl diphosphate synthetase

Dehydrodolichyl diphosphate (dedol-PP) synthase catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins; DHDDS shares 41.8% homology with yeast dedol-PP synthase and 37.6% homology with E. coli UPS; RefSeq NM_024887 (human); NM_026144 (mouse)

Also Known As:

DDDP synthetase; DEDOL-PP synthase, Arabidopsis; DHDDS protein, human; Dehydrodolichyl diphosphate synthase, mouse; Dhdds protein, mouse; dehydrodolichyl diphosphate synthase; dehydrodolichyl diphosphate synthase protein, human; dehydrodolichyl diphosphate synthase, Arabidopsis; dehydrodolichyl diphosphate synthase, rat

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Alkyl and Aryl Transferases: 180
      - dehydrodolichyl diphosphate synthetase: 7

Experts

1.	Mizrahi-Meissonnier, Liliana: 2 articles (01/2021 - 02/2011)
2.	Sharon, Dror: 2 articles (01/2021 - 02/2011)
3.	Cui, Suping: 1 article (06/2022)
4.	Li, Rui: 1 article (06/2022)
5.	Liu, Honggang: 1 article (06/2022)
6.	Piao, Yingshi: 1 article (06/2022)
7.	Xing, Li: 1 article (06/2022)
8.	Zhang, Yong: 1 article (06/2022)
9.	Li, Jun: 1 article (01/2022)
10.	Liu, Wangrui: 1 article (01/2022)

Related Diseases

1.	Seizures (Absence Seizure) 08/01/2023 - "The objective of this study is to analyze the role of dehydrodolichyl diphosphate synthase (DHDDS), a crucial enzyme in the mevalonate pathway, and its encoded mutations in the onset of developmental delay and seizures, with or without movement abnormalities. "
2.	Retinitis Pigmentosa (Pigmentary Retinopathy) 01/01/2020 - "Patients with certain defects in the dehydrodolichyl diphosphate synthase (DHDDS) gene (RP59; OMIM #613861) exhibit classic symptoms of retinitis pigmentosa, as well as macular changes, suggestive of retinal pigment epithelium (RPE) involvement. " 02/11/2011 - "A missense mutation in DHDDS, encoding dehydrodolichyl diphosphate synthase, is associated with autosomal-recessive retinitis pigmentosa in Ashkenazi Jews."
3.	Retinal Degeneration 01/01/2021 - "Knockdown of Dehydrodolichyl Diphosphate Synthase in the Drosophila Retina Leads to a Unique Pattern of Retinal Degeneration." 01/01/2020 - "Selective Ablation of Dehydrodolichyl Diphosphate Synthase in Murine Retinal Pigment Epithelium (RPE) Causes RPE Atrophy and Retinal Degeneration."
4.	Neurodevelopmental Disorders 08/01/2023 - "Case analysis of epilepsy, neurodevelopmental disorder, and motor disorders associated with mutations in the dehydrodolichyl diphosphate synthase gene."
5.	Triple Negative Breast Neoplasms 06/01/2022 - "Circular RNA dehydrodolichyl diphosphate synthase facilitated triple-negative breast cancer progression via miR-362-3p/DDX5 axis."

Related Drugs and Biologics

1.	Mevalonic Acid (Mevalonate)
2.	Enzymes
3.	Circular RNA