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motapizone

structure given in first source

Also Known As:

4,5-dihydro-6-(4-(1H-imidazol-1-yl)-2-thienyl)-5-methyl-3(2H)-pyridazinone; NAT 05239; NAT-05-239

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridazines: 11
    - motapizone: 2

Experts

1.	Gall, Henning: 1 article (07/2005)
2.	Ghofrani, Hossein Ardeschir: 1 article (07/2005)
3.	Grimminger, Friedrich: 1 article (07/2005)
4.	Inholte, Christiane: 1 article (07/2005)
5.	Schermuly, Ralph Theo: 1 article (07/2005)
6.	Seeger, Werner: 1 article (07/2005)
7.	Weidenbach, Andreas: 1 article (07/2005)
8.	Weissmann, Norbert: 1 article (07/2005)
9.	Ghofrani, H A: 1 article (02/2000)
10.	Grimminger, F: 1 article (02/2000)

Related Diseases

1.	Pulmonary Hypertension 07/20/2005 - "In catheterized rabbits with acute pulmonary hypertension induced by continuous infusion of the stable thromboxane analogue U46619, we asked whether sildenafil (PDE1/5/6 inhibitor), motapizone (PDE3 inhibitor) or 8-Methoxymethyl-IBMX (PDE1 inhibitor) synergize with inhaled iloprost. "
2.	Edema (Dropsy) 02/01/2000 - "The most effective approach, rolipram plus motapizone, amplified the maximum pPA decrease in response to PGI(2) to approximately 9 to 10 mm Hg, prolonged the post-PGI(2) vasorelaxation to >60 min, reduced the extent of lung edema formation by 50%, and decreased the shunt flow to approximately 19% (i.v. rolipram/motapizone) and 28% (aerosolized rolipram/motapizone). "

Related Drugs and Biologics

1.	Phosphodiesterase 3 Inhibitors
2.	Rolipram
3.	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
4.	Iloprost (Ventavis)
5.	Thromboxanes
6.	Sildenafil Citrate (Viagra)