9,10-epoxy-12-octadecenoic acid

toxic metabolite of leukocytes; causes cardiac failure in dogs; RN given refers to cpd without isomeric designation

Also Known As:

9,10-epoxy-12-octadecenoate; 9,10-epoxy-12-octadecenoic acid, (2alpha,3alpha(Z))-isomer

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

1.	Harrell, Maddison D: 1 article (10/2002)
2.	Stimers, Joseph R: 1 article (10/2002)

1.	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/01/1991 - "Leukotoxin, 9,10-epoxy-12-octadecenoate, as a burn toxin causing adult respiratory distress syndrome." 03/01/1988 - "Existence of leukotoxin 9,10-epoxy-12-octadecenoate in lung lavages from rats breathing pure oxygen and from patients with the adult respiratory distress syndrome."
2.	Burns 01/01/1990 - "Proposal of leukotoxin, 9,10-epoxy-12-octadecenoate, as a burn toxin." 01/01/1991 - "Leukotoxin, 9,10-epoxy-12-octadecenoate, as a burn toxin causing adult respiratory distress syndrome."
3.	Acute Lung Injury 09/01/1996 - "We tested the hypothesis that BQ-123, a novel endothelin type A (ETA) receptor antagonist, protects the lung against leukotoxin 9,10-epoxy-12-octadecenoate (Lx), which causes acute lung injury in animals. "
4.	Lung Injury 07/01/1995 - "Leukotoxin, 9,10-epoxy-12-octadecenoate causes edematous lung injury via activation of vascular nitric oxide synthase." 07/01/1995 - "We examined the mechanism of leukotoxin, 9,10-epoxy-12-octadecenoate (Lx)-induced lung injury in blood-free, physiological salt solution-perfused rat lungs under constant flow conditions. "
5.	Pulmonary Edema 01/01/1988 - "Neutrophil-derived epoxide, 9,10-epoxy-12-octadecenoate, induces pulmonary edema."

1.	leukotoxin
2.	Linoleic Acid (Linoleate)
3.	Nitric Oxide Synthase (NO Synthase)
4.	Endothelins (Endothelin)
5.	Solutions
6.	Salts
7.	Oxygen (Dioxygen)
8.	Epoxy Compounds (Epoxides)
9.	cyclo(Trp-Asp-Pro-Val-Leu)