tubeimoside I

a phytogenic antineoplastic agent with antiviral and anti-inflammatory activities; from Chinese Cucurbitaceae folk medicine "tu bei mu" a tuber of Bolbostemma paniculatum; structure given in second source

Also Known As:

Networked: 50 relevant articles (4 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yan, Jianghong: 5 articles (08/2021 - 08/2019)
2.	Luo, Minghao: 4 articles (08/2021 - 06/2020)
3.	Luo, Suxin: 4 articles (08/2021 - 06/2020)
4.	Yang, Xiyang: 4 articles (08/2021 - 06/2020)
5.	Zhang, Yi: 4 articles (07/2019 - 01/2011)
6.	Cheng, Zhe: 3 articles (08/2021 - 06/2020)
7.	Guo, Yongzheng: 3 articles (08/2021 - 06/2020)
8.	Huang, Bi: 3 articles (08/2021 - 01/2021)
9.	Huang, Longxiang: 3 articles (08/2021 - 01/2021)
10.	Li, Chang: 3 articles (08/2021 - 06/2020)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2014 - "Of the different extracts from traditional Chinese medicines, Tubeimoside 1 (TBMS 1) is regarded as an effective treatment for cancer. " 08/14/2019 - "Tubeimoside-I (TBM), a plant-derived bioactive compound, shows antitumor activity in different tumors and can enhance the efficacy of chemotherapeutic agents. " 01/01/2018 - "The aim of this study is to establish and validate a rapid, selective, and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method to determine tubeimoside I (TBMS-I) in ICR (Institute of Cancer Research) mouse whole blood and its application in the pharmacokinetics and bioavailability study. " 07/24/2023 - "Tubeimoside-1 (TBMS-1), a traditional Chinese medicinal herb, is commonly used as an anti-cancer agent. " 01/01/2020 - "Tubeimoside-1 (TBMS1), a traditional Chinese herb extracted from Bolbostemma paniculatum (Maxim.), induces apoptosis in a number of human cancer cell lines. "
2.	Cardiotoxicity 01/01/2023 - "The role of tubeimoside I (TBM) in DOX-induced cardiotoxicity remains ambiguous, despite growing evidence that it could reduce inflammation, oxidative stress, and apoptosis in various diseases. " 01/01/2023 - "Tubeimoside I Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating SIRT3."
3.	Myocardial Ischemia (Ischemic Heart Diseases) 01/01/2021 - "Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis."
4.	Reperfusion Injury 01/01/2021 - "Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis."
5.	Sepsis (Septicemia) 01/01/2021 - "In this study, we detected a favorable effect of tubeimoside I (TBM) in ameliorating sepsis-induced endothelial dysfunction. " 08/15/2021 - "Tubeimoside I protects against sepsis-induced cardiac dysfunction via SIRT3." 01/01/2021 - "Tubeimoside I improves endothelial function in sepsis via activation of SIRT3." 06/01/2020 - "Tubeimoside I improves survival of mice in sepsis by inhibiting inducible nitric oxide synthase expression." 08/01/2013 - "Acute lung injury (ALI), characterized by severe hypoxemia, pulmonary edema and neutrophil accumulation in the lung, is a common clinical problem associated with significant morbidity and mortality in shock, sepsis, ischemia reperfusion, etc. In this study, we aimed at investigating the protective effect of tubeimoside-1 (TBMS1) on inflammation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and a LPS-induced in vivo lung injury model. "

Related Drugs and Biologics

1.	Sirtuin 3
2.	Doxorubicin (Adriamycin)
3.	Lipopolysaccharides
4.	Particulate Matter
5.	Triterpenes
6.	Saponins
7.	Cytochromes c (Cytochrome c)
8.	Arachidonic Acid (Vitamin F)
9.	Antineoplastic Agents (Antineoplastics)
10.	tubeimoside III

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
2.	Drug Therapy (Chemotherapy)
3.	Immunomodulation
4.	Chemoprevention
5.	Oral Administration