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mitometh
less toxic than mitotane; structure given in first source
Also Known As:
1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloropropane; 2,2-DDP; 2,2-dichloro-1-(2-chlorophenyl)-1-(4-chlorophenyl)propane; Benzene, 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)propyl)-
Networked:
2
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Halogenated Hydrocarbons: 42
Chlorinated Hydrocarbons: 240
Mitotane: 664
mitometh: 2
Related Diseases
1.
Adrenal Gland Neoplasms (Adrenal Cancer)
01/01/1993 - "
This observation prompted us to undertake a comparative study of these two drugs on the basis that Mitometh may be a superior agent for the treatment of adrenal cancer.
"
01/01/1993 - "
We conclude that Mitometh is not likely to be effective in the therapy of adrenal cancer.
"
2.
Adrenocortical Carcinoma
01/01/1987 - "
Mitometh represents a potential alternative to Lysodren which should be investigated further for its possible use in the treatment of adrenal cortical carcinoma and Cushing's syndrome.
"
3.
Necrosis
01/01/1993 - "
Despite the lack of adrenalytic activity, Mitometh maintained its toxicity as demonstrated by microscopic evidence of hepatic necrosis and an increase in hepatic enzymes.
"
01/01/1993 - "
Whereas the adrenal glands of Mitotane-treated dogs showed hemorrhage and necrosis, the Mitometh-treated animals showed no adrenal damage.
"
4.
Hemorrhage
01/01/1993 - "
Whereas the adrenal glands of Mitotane-treated dogs showed hemorrhage and necrosis, the Mitometh-treated animals showed no adrenal damage.
"
5.
Diarrhea
01/01/1987 - "
In general the animals treated with Mitometh showed less alopecia, diarrhea, and weakness.
"
Related Drugs and Biologics
1.
Mitotane (Lysodren)
2.
Enzymes
Related Therapies and Procedures
1.
Therapeutics