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insulin-related factor

MW 6-kDa; from insulin-independent cell line 1246-3A; similar to pancreatic insulin; has growth-promoting activity

Also Known As:

insulin-related growth factor

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Peptide Hormones: 1347
    - Pancreatic Hormones: 113
      - Insulins: 644
        Proinsulin: 1195
        Insulin: 113363
        insulin-related factor: 5
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Peptide Hormones: 1347
    - Pancreatic Hormones: 113
      - Insulins: 644
        Proinsulin: 1195
        Insulin: 113363
        insulin-related factor: 5

Related Diseases

1.	Teratoma (Teratoid Tumor) 01/05/1987 - "Purification of an insulin-related factor secreted by a teratoma-derived mesodermal cell line." 03/13/1986 - "Characterization of an insulin-related factor secreted by a teratoma cell line." 08/01/1988 - "Autocrine growth induced by the insulin-related factor in the insulin-independent teratoma cell line 1246-3A." 01/05/1987 - "Insulin-related factor (IRF), a polypeptide secreted by the mouse teratoma-derived cell line (1246-3A), was purified 3210-fold to homogeneity from 1246-3A conditioned medium using a rapid three-step procedure including cation-exchange chromatography, immunoaffinity chromatography using a monoclonal antibody against porcine insulin coupled to an agarose gel support, and reverse phase high performance liquid chromatography. "
2.	Knee Osteoarthritis 03/01/1993 - "Levels of insulin related growth factor 1 in osteoarthritis of the knee."
3.	Myeloid Leukemia (Leukemia, Myelocytic) 04/01/1986 - "It appears that autocrine stimulation of murine myeloid leukemia can be mediated in part by an insulin-related growth factor."

Related Drugs and Biologics

1.	Pork Regular Insulin (Velosulin)
2.	Conditioned Culture Media
3.	Sepharose (Agarose)
4.	Peptides (Polypeptides)
5.	Insulin (Novolin)
6.	Cations
7.	Monoclonal Antibodies