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1,2-dihydroxynaphthalene

RN given refers to parent cpd

Also Known As:

1,2-dihydroxynaphthalene monohydrate; 1,2-naphthalenediol

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Naphthols: 64
        1,2-dihydroxynaphthalene: 5
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Naphthols: 64
      - 1,2-dihydroxynaphthalene: 5

Experts

1.	Cavalieri, Ercole: 1 article (10/2009)
2.	Chakravarti, Dhrubajyoti: 1 article (10/2009)
3.	Gaikwad, Nilesh: 1 article (10/2009)
4.	Higginbotham, Sheila: 1 article (10/2009)
5.	Rogan, Eleanor: 1 article (10/2009)
6.	Saeed, Muhammad: 1 article (10/2009)
7.	Huang, Chuan-Chen: 1 article (02/2007)
8.	Lin, Chia-Hua: 1 article (02/2007)
9.	Lin, Po-Hsiung: 1 article (02/2007)
10.	Wang, Tzu-Wen: 1 article (02/2007)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 02/20/2007 - "The purpose of this study is to examine the differences in the induction of cytotoxic effects and poly(ADP-ribose) polymerase-1 activation in human MCF-7 breast cancer cells by quinonoid derivatives of naphthalene, including 1,2-naphthalenediol (NCAT), 1,4-naphthalenediol (NHQ), 1,2-naphthoquinone (1,2-NQ), and 1,4-naphthoquinone (1,4-NQ). "
2.	Cataract (Cataracts) 10/01/1993 - "This suggests that aldose reductase is linked to 1,2-dihydroxynaphthalene formation in rat lens and the subsequent formation of cataracts in naphthalene-fed rats." 04/01/1996 - "Based on these results, it was concluded that the prevention of the naphthalene cataract probably results from inhibition of the conversion of naphthalene dihydrodiol to 1,2-dihydroxynaphthalene and that the effect of the ARIs cannot be explained by their inhibition of the dihydrodiol dehydrogenase activity of aldose reductase." 01/01/1992 - "Other naphthalene metabolites such as 1-naphthol, 2-naphthol, 1,2-dihydroxynaphthalene and 1,2-naphthoquinone were also studied in vitro and the results showed that the effects of these naphthalene metabolites were very different from those observed in naphthalene cataracts in vivo."
3.	Neoplasms (Cancer) 10/01/2009 - "To investigate its mechanism of metabolic activation and cancer initiation, mice were topically treated with naphthalene or one of its metabolites, 1-naphthol, 1,2-dihydrodiolnaphthalene (1,2-DDN), 1,2-dihydroxynaphthalene (1,2-DHN), and 1,2-naphthoquinone (1,2-NQ). "

Related Drugs and Biologics

1.	naphthalene
2.	1,2-naphthoquinone
3.	Poly (ADP-Ribose) Polymerase-1
4.	1,4-naphthoquinone
5.	Aldehyde Reductase (Aldose Reductase)
6.	1-naphthol (alpha-naphthol)
7.	trans-1,2-dihydro-1,2-naphthalenediol
8.	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (dihydrodiol dehydrogenase)
9.	2-naphthol