glycylpeptide N-tetradecanoyltransferase

from yeast; absolutely specific for attachment of myristic acid to amino-terminal glycine residues of proteins

Also Known As:

N-myristoyltransferase; glycylpeptide-N-myristoyl transferase; glycylpeptide-N-myristoyltransferase; myristoyl CoA-glycylpeptide-N-myristoyltransferase; myristoyl CoA-protein N-myristoyltransferase; myristoyl coenzyme A-protein N-myristoyltransferase; protein N-myristoyl transferase

Networked: 74 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - glycylpeptide N-tetradecanoyltransferase: 74

Experts

1.	Tate, Edward W: 15 articles (01/2019 - 03/2010)
2.	Sharma, Rajendra K: 15 articles (03/2011 - 01/2002)
3.	Brannigan, James A: 11 articles (10/2015 - 03/2010)
4.	Wilkinson, Anthony J: 11 articles (10/2015 - 03/2010)
5.	Leatherbarrow, Robin J: 10 articles (10/2015 - 03/2010)
6.	Shrivastav, Anuraag: 9 articles (01/2018 - 01/2005)
7.	Wyatt, Paul G: 7 articles (10/2020 - 04/2010)
8.	Selvakumar, Ponniah: 7 articles (05/2007 - 10/2002)
9.	Holder, Anthony A: 6 articles (01/2018 - 01/2012)
10.	Smith, Deborah F: 6 articles (06/2016 - 03/2010)

Related Diseases

1.	Neoplasms (Cancer) 10/22/2020 - "Because cancer cells often have increased N-myristoyltransferase (NMT) expression, NMTs were proposed as anti-cancer targets. " 01/01/2016 - "N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells." 07/01/2009 - "Overexpression of Akt/PKB modulates N-myristoyltransferase activity in cancer cells." 01/01/2007 - "Potential role of N-myristoyltransferase in cancer." 11/01/1995 - "Increased N-myristoyltransferase activity was also observed in human colonic tumors and was predominantly cytosolic. "
2.	Malaria 01/01/2018 - "N-Myristoylation as a Drug Target in Malaria: Exploring the Role of N-Myristoyltransferase Substrates in the Inhibitor Mode of Action." 02/01/2014 - "We demonstrate that N-myristoyltransferase is an essential and chemically tractable target in malaria parasites both in vitro and in vivo, and show that selective inhibition of N-myristoylation leads to catastrophic and irreversible failure to assemble the inner membrane complex, a critical subcellular organelle in the parasite life cycle. " 06/01/2000 - "The gene coding for myristoyl-CoA:protein N-myristoyltransferase (NMT) has been cloned from the malaria parasite Plasmodium falciparum. " 08/26/2022 - "N-myristoyltransferase (NMT) inhibitors that were initially developed for treatment of parasitic protozoan infections, including sleeping sickness, malaria, and leismaniasis, have also shown great promise as treatment for oncological diseases. " 10/08/2015 - "N-Myristoyltransferase (NMT) represents an attractive drug target in parasitic infections such as malaria due to its genetic essentiality and amenability to inhibition by drug-like small molecules. "
3.	Carcinogenesis 11/01/1995 - "This study demonstrates for the first time that N-myristoyltransferase activity is higher in colonic epithelial neoplasms than in normal-appearing colonic tissue and that an increase in N-myristoyltransferase activity appears at an early stage in colonic carcinogenesis." 07/14/2000 - "Earlier, we have reported that N-myristoyltransferase (NMT) activity is higher in colonic epithelial neoplasms than in normal appearing colonic tissue and that increase in NMT activity appears at an early stage in colonic carcinogenesis [Magnuson, B., Raju, R. " 07/01/2007 - "N-myristoyltransferase (NMT) catalyzes the myristoylation of proteins involved in signal transduction, cellular transformation, differentiation, proliferation and oncogenesis. " 01/15/2008 - "N-myristoyltransferase (NMT) exists in two isoforms, NMT1 and NMT2, that catalyze myristoylation of various proteins crucial in signal transduction, cellular transformation, and oncogenesis. " 01/01/2005 - "Based on our previous findings of elevated N-myristoyltransferase (NMT) activity in colonic epithelial neoplasms that appears at an early stage in colonic carcinogenesis, together with elevated NMT expression in human colorectal and gallbladder carcinomas, we investigated NMT activity and protein expression of NMT1 and NMT2 in human brain tumors and documented elevated NMT activity and higher protein expressions. "
4.	Leishmaniasis 10/23/2014 - "Inhibitors of Leishmania N-myristoyltransferase (NMT), a potential target for the treatment of leishmaniasis, obtained from a high-throughput screen, were resynthesized to validate activity. " 07/01/2014 - "The need for an effective oral therapy for leishmaniasis is addressed through the study of the target N-myristoyltransferase from Leishmania major. " 01/01/2014 - "N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis." 11/03/2023 - "Screening of potential inhibitors of Leishmania major N-myristoyltransferase from Azadirachta indica phytochemicals for leishmaniasis drug discovery by molecular docking, molecular dynamics simulation and density functional theory methods." 11/07/2014 - "Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites."
5.	Colonic Neoplasms (Colon Cancer) 11/16/2007 - "N-myristoyltransferase: a potential novel diagnostic marker for colon cancer." 03/16/2011 - "The potential use of N-myristoyltransferase as a biomarker in the early diagnosis of colon cancer." 07/14/2000 - "Expression of N-myristoyltransferase inhibitor protein and its relationship to c-Src levels in human colon cancer cell lines." 11/01/1995 - "The purpose of this study was twofold: 1) to investigate the activity of N-myristoyltransferase in azoxymethane-induced rat colonic cancer tissue compared with normal and normal-appearing rat colonic tissue and 2) to determine if similar differences would be observed in a small sample of human colonic tumors. " 05/01/2007 - "Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review)."

Related Drugs and Biologics

1.	Decoquinate
2.	Azoxymethane
3.	Antimalarials (Antimalarial Agents)
4.	NITD 609
5.	ferroquine
6.	benzothiophene
7.	usnic acid
8.	tafenoquine
9.	WEHI-916
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics