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indolidan
structure given in first source
Also Known As:
1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H-indol-2-one; LY 195115; LY-195115
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Alkaloids: 5398
Indole Alkaloids: 200
Oxindoles: 118
indolidan: 3
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
Indole Alkaloids: 200
Oxindoles: 118
indolidan: 3
Indolizines: 3
Indolizidines: 2
Indole Alkaloids: 200
Oxindoles: 118
indolidan: 3
Related Diseases
1.
Pheochromocytoma
04/21/1995 - "
Indolidan and a variety of nongenotoxic agents that cause pheochromocytomas in rats may do so indirectly by increasing neurally mediated chromaffin cell turnover.
"
04/21/1995 - "
The mitogenic effects of PACAP are potentiated by indolidan, a phosphodiesterase inhibitor known to cause pheochromocytomas in rats, and are inhibited by H-89, an inhibitor of protein kinase A.
"
2.
Heart Failure
10/01/1992 - "
Clinical effect of indolidan in congestive heart failure.
"
3.
Cardiovascular Diseases (Cardiovascular Disease)
01/01/1991 - "
Fifty-four percent of the male rats treated with 48.0 mg/kg isomazole and 55% of the male rats treated with 1.3 mg/kg indolidan died from cardiovascular disease compared to 1-2% among the control males.
"
Related Drugs and Biologics
1.
Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)
2.
Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)
3.
Phosphodiesterase Inhibitors
4.
N- (2- (4- bromocinnamylamino)ethyl)- 5- isoquinolinesulfonamide (h89)
5.
sulmazole (Vardax)