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nootkatone

RN given refers to cpd without isomeric designation; structure given in first source

Also Known As:

nootkatone, (4R-(4alpha,4aalpha,6beta))-isomer

Networked: 37 relevant articles (4 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - Polycyclic Sesquiterpenes: 9
        nootkatone: 37
Polycyclic Compounds: 6
- Polycyclic Sesquiterpenes: 9
  - nootkatone: 37

Experts

1.	Jia, Ying: 5 articles (04/2021 - 01/2018)
2.	Yan, Tingxu: 5 articles (04/2021 - 01/2018)
3.	Wu, Bo: 4 articles (04/2021 - 01/2018)
4.	Xiao, Feng: 4 articles (04/2021 - 01/2018)
5.	Bi, Kaishun: 4 articles (03/2020 - 01/2018)
6.	Al-Salam, Suhail: 3 articles (01/2019 - 01/2018)
7.	Ali, Badreldin H: 3 articles (01/2019 - 01/2018)
8.	Beegam, Sumaya: 3 articles (01/2019 - 01/2018)
9.	Nemmar, Abderrahim: 3 articles (01/2019 - 01/2018)
10.	Yuvaraju, Priya: 3 articles (01/2019 - 01/2018)

Related Diseases

1.	Myocardial Infarction 04/01/2021 - "Nootkatone attenuates myocardial oxidative damage, inflammation, and apoptosis in isoproterenol-induced myocardial infarction in rats." 11/30/2020 - "In the present study, we assessed whether nootkatone (NKT), a sesquiterpene in edible plants, can provide protection against dyslipidemia, intramyocardial lipid accumulation, and altered lipid metabolism in a rat model of myocardial infarction (MI) induced by subcutaneous injections of isoproterenol (ISO, 85 mg/kg) on days 9 and 10. "
2.	Fibrosis (Cirrhosis) 11/01/2021 - "Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model." 11/05/2021 - "In the present study, we investigated the renoprotective and antifibrotic potential of nootkatone (NTK), a bioactive sesquiterpene, in an experimental model of renal fibrosis. "
3.	Dyslipidemias (Dyslipidemia) 11/30/2020 - "Nootkatone, a Dietary Fragrant Bioactive Compound, Attenuates Dyslipidemia and Intramyocardial Lipid Accumulation and Favorably Alters Lipid Metabolism in a Rat Model of Myocardial Injury: An In Vivo and In Vitro Study." 11/30/2020 - "In the present study, we assessed whether nootkatone (NKT), a sesquiterpene in edible plants, can provide protection against dyslipidemia, intramyocardial lipid accumulation, and altered lipid metabolism in a rat model of myocardial infarction (MI) induced by subcutaneous injections of isoproterenol (ISO, 85 mg/kg) on days 9 and 10. "
4.	Inflammation (Inflammations) 07/19/2023 - "Nootkatone (NKT) exhibits potential pharmacological activities including anti-oxidation and anti-inflammation. " 11/01/2021 - "Further analysis showed that nootkatone suppressed inflammation and protected cartilage against degeneration induced by ACLT surgery in mice. " 01/01/2019 - "We conclude that nootkatone ameliorated the WPS-induced testicular inflammation and oxidative stress and hormonal and spermatogenesis alterations." 11/01/2021 - "Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model." 02/01/2018 - "Nootkatone confers hepatoprotective and anti-fibrotic actions in a murine model of liver fibrosis by suppressing oxidative stress, inflammation, and apoptosis."
5.	Lung Injury 02/26/2018 - "In Vivo Protective Effects of Nootkatone against Particles-Induced Lung Injury Caused by Diesel Exhaust Is Mediated via the NF-κB Pathway."

Related Drugs and Biologics

1.	Sesquiterpenes
2.	Isoproterenol (Isoprenaline)
3.	Lipids
4.	Vehicle Emissions (Emissions, Vehicle)
5.	Ketones
6.	Neuroprotective Agents
7.	Therapeutic Uses
8.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
9.	Biomarkers (Surrogate Marker)
10.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Subcutaneous Injections