HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

9- (1- hydroxy- 4- phosphinyl- 2- butoxymethyl)guanine

structure given in first source

Also Known As:

HPBMG; SR 3773; SR-3773; SR3773

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Hypoxanthines: 1
        Guanine: 1793
        Acyclovir: 4814
        Ganciclovir: 3793
        9-(1-hydroxy-4-phosphinyl-2-butoxymethyl)guanine: 2

Related Diseases

1.	Body Weight (Weight, Body) 08/01/1996 - "However, whereas SR3773 caused 20 to 30% destruction of renal tubules at 50 mg/kg of body weight per day (but exerted no toxicity at 25 mg/kg/day), SR3775 showed no deleterious renal effects at 600 mg/kg/day over 14 days. " 09/01/1994 - "In severe combined immunodeficient mice infected with murine cytomegalovirus, SR3773 and SR3745A (12.5, 25, and 50 mg/kg of body weight per day) were superior to ganciclovir in extending the mean time to death, whereas SR3722 and SR3772 was less potent than ganciclovir. "
2.	Infections 08/01/1996 - "SR3775 was about half as active as SR3773 against MCMV infections in severe combined immunodeficient mice. "
3.	Cytomegalovirus Infections (Inclusion Disease) 09/01/1994 - "These results suggest that SR3773 may have potential for use in the treatment of human cytomegalovirus infections, but it may also exhibit renal toxicity."

Related Drugs and Biologics

1.	Ganciclovir (Cytovene)
2.	ganciclovir cyclic phosphonate