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compound FP 1

structure given in first source

Also Known As:

FP-1; N-(4-(2-fluorobenzoyl)-1,3-dimethyl-1H-pyrazol-5-yl)-2-((3-(2-methyl-1-piperidinyl)propyl)amino)acetamide-2-butenedioate(1:2)

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - compound FP 1: 7

Experts

1.	Aigner, Elmar: 2 articles (08/2008 - 05/2008)
2.	Datz, Christian: 2 articles (08/2008 - 05/2008)
3.	Haufe, Heike: 2 articles (08/2008 - 05/2008)
4.	Theurl, Igor: 2 articles (08/2008 - 05/2008)
5.	Du, Lupei: 1 article (10/2019)
6.	Feng, Ping: 1 article (10/2019)
7.	Gou, Xueyan: 1 article (10/2019)
8.	Ke, Bowen: 1 article (10/2019)
9.	Li, Minyong: 1 article (10/2019)
10.	Ma, Lin: 1 article (10/2019)

Related Diseases

1.	Non-alcoholic Fatty Liver Disease 05/01/2008 - "Increased hepcidin formation in iron-overloaded NAFLD patients, however, results in decreased duodenal FP-1 expression, whereas a reduction in liver FP-1 may perpetuate hepatic iron retention. " 08/01/2008 - "Our results indicate that copper status is linked to iron homeostasis in NAFLD, suggesting that low copper bioavailability causes increased hepatic iron stores via decreased FP-1 expression and ceruloplasmin ferroxidase activity thus blocking liver iron export in copper-deficient subjects." 05/01/2008 - "Hepatic mRNA and serum protein concentrations of tumor necrosis factor-alpha (TNF-alpha) were increased in NAFLD patients and were inversely correlated with both liver FP-1 and HJV mRNA and positively associated with body mass index and hepatic hepcidin mRNA. " 05/01/2008 - "The mRNA expression of the iron-regulatory peptide hepcidin was increased in NAFLD patients with iron overload, which was paralleled by low duodenal FP-1 expression. "
2.	Neoplasms (Cancer) 02/01/1991 - "Upon screening various tumor tissues, FP-1 was found to react with adenocarcinomas of the pancreas (16/23), stomach (7/8), colon (4/6) and gall bladder (2/2) as well as with the three malignant cell lines, PANC-1 (pancreas), HT-29 (colon) and LoVo (colon). " 09/01/1986 - "Additional mammary gland neoplasms were found at necropsy or on histopathologic examination of mammary glands from rats receiving FP-1, FP-2, and the FP nucleus. "
3.	Iron Overload 05/01/2008 - "The mRNA expression of the iron-regulatory peptide hepcidin was increased in NAFLD patients with iron overload, which was paralleled by low duodenal FP-1 expression. "
4.	Sepsis (Septicemia) 10/01/2019 - "FP-1 not only can detect accumulations of exogenous Fe2+ in living animal, but also has the capability of monitoring labile endogenous Fe2+ levels in animal model of sepsis. "
5.	Neuralgia (Stump Neuralgia) 09/01/2008 - "Together, our findings support the previous evidence indicative for a contribution of glial TLR4 to the initiation of neuropathic pain, suggest it as potential innovative target to treat this debilitating disease, and propose FP-1 as lead compound for the development of new effective drugs."

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Iron
3.	compound FP 2
4.	Hepcidins
5.	TOR Serine-Threonine Kinases
6.	Toll-Like Receptor 4
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Messenger RNA (mRNA)
9.	Myosins (Myosin)
10.	Copper