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1-hydroxyphenazine

a virulence factor of Pseudomonas aeruginosa

Also Known As:

1-Phenazinol

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Phenazines: 42
      - 1-hydroxyphenazine: 11

Experts

1.	Gong, Dafei: 1 article (07/2021)
2.	Lin, Wanhua: 1 article (07/2021)
3.	Liu, Tingting: 1 article (07/2021)
4.	Lu, ZuJun: 1 article (07/2021)
5.	Shang, Changhua: 1 article (07/2021)
6.	Thwe, Aye Aye: 1 article (07/2021)
7.	Xiao, Jun: 1 article (07/2021)
8.	Guo, Shuqi: 1 article (01/2020)
9.	Hu, Hongbo: 1 article (01/2020)
10.	Li, Zhiyong: 1 article (01/2020)

Related Diseases

1.	Astrocytoma (Pilocytic Astrocytoma) 02/01/2012 - "In conclusion, this study provides the first evidence on mechanisms underlying the toxicity of both pyocyanin and 1-hydroxyphenazine to astrocytoma cells and provides novel evidence suggesting that this toxicity may be mediated by the formation of acidic vesicular organelles, a hallmark of autophagic cell death." 02/01/2012 - "Therefore, the aim of this study was to compare the CNS toxicity of pyocyanin and 1-hydroxyphenazine in vitro and to provide insight into mechanisms that underlie this toxicity using 1321N1 astrocytoma cells. "
2.	Cystic Fibrosis (Mucoviscidosis) 12/12/1995 - "The airways of cystic fibrosis patients colonised by Pseudomonas aeruginosa contain the redox active phenazine derivative, 1-hydroxyphenazine (OHP). " 11/01/1995 - "The phenazine derivative, 1-hydroxyphenazine (OHP), is produced in vivo by Pseudomonas aeruginosa, an organism that colonises the airways of patients with cystic fibrosis. " 12/12/1995 - "Scavenging of neutrophil-derived superoxide anion by 1-hydroxyphenazine, a phenazine derivative associated with chronic Pseudomonas aeruginosa infection: relevance to cystic fibrosis." 09/01/1988 - "The phenazine pigments pyocyanin and 1-hydroxyphenazine were resolved by high-pressure liquid chromatography from the sputum sol phase from 9 of 13 patients with cystic fibrosis or bronchiectasis colonized by Pseudomonas aeruginosa. "
3.	Pseudomonas Infections 02/02/2016 - "Immunochemical Determination of Pyocyanin and 1-Hydroxyphenazine as Potential Biomarkers of Pseudomonas aeruginosa Infections." 12/12/1995 - "Scavenging of neutrophil-derived superoxide anion by 1-hydroxyphenazine, a phenazine derivative associated with chronic Pseudomonas aeruginosa infection: relevance to cystic fibrosis."
4.	Dyskinesias (Dyskinesia) 01/01/1987 - "1-hydroxyphenazine caused rapid onset of ciliary slowing associated with dyskinesia and ciliostasis. "
5.	Neoplasms (Cancer) 01/01/2020 - "Additionally, 1-hydroxyphenazine N'10-oxide demonstrated substantial cytotoxic activity against two human cancer cell lines, MCF-7 and HT-29. "

Related Drugs and Biologics

1.	Pyocyanine
2.	phenazine
3.	Polymethyl Methacrylate (Sol)
4.	Biomarkers (Surrogate Marker)
5.	Superoxides (Superoxide)
6.	5-methylphenazine-1-carboxylic acid