2-bromo-2'-deoxyadenosine

Also Known As:

2'-deoxy-2-bromoadenosine; BrdAdo

Networked: 5 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleosides: 360
        Adenosine: 12431
        Deoxyadenosines: 1
        2-bromo-2'-deoxyadenosine: 5
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Purine Nucleosides: 360
    - Adenosine: 12431
      - Deoxyadenosines: 1
        2-bromo-2'-deoxyadenosine: 5
  - Deoxyribonucleosides: 34
    - Deoxyadenosines: 1
      - 2-bromo-2'-deoxyadenosine: 5

Related Diseases

1.	Neoplasms (Cancer) 06/01/1984 - "A more convenient synthetic route to 2-bromo-2'-deoxyadenosine (5) is reported, and results indicating significant antitumor activity of 5 against three murine tumors (L1210 leukemia, B16 melanoma, and M5076 ovarian carcinoma) are presented. " 11/01/1995 - "2-Chloro-2'-deoxyadenosine (CldAdo), a nucleoside that has proven useful in the treatment of several chronic lymphoid malignancies, and its analogue, 2-bromo-2'-deoxyadenosine, are both effective inhibitors of the bacterial (Escherichia coli) purine-nucleoside phosphorylase (PNP), with Ki values of 4.5 microM and 6.3 microM, respectively. "
2.	Melanoma (Melanoma, Malignant) 11/15/1986 - "In further studies of BrdAdo a third sensitive melanoma line was identified of the eight tested. "
3.	Leukemia L1210 06/01/1984 - "A more convenient synthetic route to 2-bromo-2'-deoxyadenosine (5) is reported, and results indicating significant antitumor activity of 5 against three murine tumors (L1210 leukemia, B16 melanoma, and M5076 ovarian carcinoma) are presented. " 09/15/1989 - "Mice inoculated with L1210 leukemia were treated with 2-bromo-2'-deoxyadenosine (BrdAdo) paired with one of 18 other therapeutic agents. "
4.	Experimental Melanoma 06/01/1984 - "A more convenient synthetic route to 2-bromo-2'-deoxyadenosine (5) is reported, and results indicating significant antitumor activity of 5 against three murine tumors (L1210 leukemia, B16 melanoma, and M5076 ovarian carcinoma) are presented. "
5.	Glioma (Gliomas) 01/01/1996 - "Mitochondrial damage following exposure of organotypic cultures of human malignant gliomas to 2-chloro- and 2-bromo-2'-deoxyadenosine." 01/01/1996 - "The effects of 2-chloro-2'-deoxyadenosine (cladribine, 2-CdA) and a closely related compound 2-bromo-2'-deoxyadenosine (2-BdA) on organotypic cultures of human malignant gliomas were studied with the use of electron microscopy. "

Related Drugs and Biologics

1.	Cladribine
2.	Purine-Nucleoside Phosphorylase
3.	Nucleosides
4.	2-bromo-2'-deoxyadenosine