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L 649923
RN refers to (+-)-isomer; structure in first source; leukotriene D4 antagonist
Also Known As:
4-((3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)thio)-gamma-hydroxy-beta-methylbenzenebutanoate; L 649923, sodium salt, (+)-isomer; L 649923, sodium salt, (+-)-isomer; L 649923, sodium salt, (-)-isomer; L-649,923
Networked:
11
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Carboxylic Acids: 973
Carbocyclic Acids
Phenylbutyrates
L 649923: 11
Related Diseases
1.
Septic Shock (Toxic Shock Syndrome)
02/01/1989 - "
These studies suggest that L-649,923 could preserve cardiac and vascular functions in pathologic states mediated by cysteinyl leukotrienes, such as traumatic or endotoxin shock.
"
2.
Hyperplasia
09/30/1988 - "
This work demonstrates that L-649,923 increases the plasma turnover of thyroxine which is associated with a stimulation of TSH and thyroid hyperplasia.
"
09/30/1988 - "
Thyroid hyperplasia and/or hepatomegaly were observed in a 14-week oral toxicity study with L-649,923, a leukotriene antagonist, at doses of 50 and 150 mg/kg/day.
"
3.
Hepatomegaly
09/30/1988 - "
Thyroid hyperplasia and/or hepatomegaly were observed in a 14-week oral toxicity study with L-649,923, a leukotriene antagonist, at doses of 50 and 150 mg/kg/day.
"
4.
Asthma (Bronchial Asthma)
08/01/1986 - "
The present findings indicate that selective antagonists, such as L-649,923, may be useful for defining the role of leukotrienes in diseases such as bronchial asthma.
"
05/01/1987 - "
We have compared the effects of the leukotriene (LT) D4 antagonist L-649,923 and placebo on the airway response to antigen challenge in eight men with mild asthma known to have both an early and late response to inhaled antigen.
"
05/01/1987 - "
The effect of an oral leukotriene D4 antagonist L-649,923 on the response to inhaled antigen in asthma.
"
01/01/1987 - "
Effect of an oral leukotriene D4 antagonist L-649,923 on the response to inhaled antigen in asthma.
"
5.
Hemorrhagic Shock
03/01/1988 - "
Our data suggest that peptide leukotrienes are important mediators of hemorrhagic shock and that blockade of leukotriene-induced vasoconstriction may underlie the beneficial effects of L-649,923 in hemorrhagic shock.
"
03/01/1988 - "
We studied the effects of a novel selective peptide leukotriene antagonist, L-649,923, in a rat model of hemorrhagic shock.
"
Related Drugs and Biologics
1.
Leukotrienes
2.
Leukotriene Antagonists (Leukotriene Receptor Antagonists)
3.
Leukotriene D4
4.
Antigens
5.
leukotriene D4 receptor (cysteinyl leukotriene receptor)
6.
Lipoxygenase Inhibitors
7.
4,5- Dihydro- 1- (3- (trifluoromethyl)phenyl)- 1H- pyrazol- 3- amine
8.
Thyroxine (Levothyroxine)
9.
Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
10.
Peptides (Polypeptides)