L 649923

RN refers to (+-)-isomer; structure in first source; leukotriene D4 antagonist

Also Known As:

4-((3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)thio)-gamma-hydroxy-beta-methylbenzenebutanoate; L 649923, sodium salt, (+)-isomer; L 649923, sodium salt, (+-)-isomer; L 649923, sodium salt, (-)-isomer; L-649,923

Networked: 11 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Phenylbutyrates
      - L 649923: 11

Related Diseases

1.	Septic Shock (Toxic Shock Syndrome) 02/01/1989 - "These studies suggest that L-649,923 could preserve cardiac and vascular functions in pathologic states mediated by cysteinyl leukotrienes, such as traumatic or endotoxin shock."
2.	Hyperplasia 09/30/1988 - "This work demonstrates that L-649,923 increases the plasma turnover of thyroxine which is associated with a stimulation of TSH and thyroid hyperplasia." 09/30/1988 - "Thyroid hyperplasia and/or hepatomegaly were observed in a 14-week oral toxicity study with L-649,923, a leukotriene antagonist, at doses of 50 and 150 mg/kg/day. "
3.	Hepatomegaly 09/30/1988 - "Thyroid hyperplasia and/or hepatomegaly were observed in a 14-week oral toxicity study with L-649,923, a leukotriene antagonist, at doses of 50 and 150 mg/kg/day. "
4.	Asthma (Bronchial Asthma) 08/01/1986 - "The present findings indicate that selective antagonists, such as L-649,923, may be useful for defining the role of leukotrienes in diseases such as bronchial asthma." 05/01/1987 - "We have compared the effects of the leukotriene (LT) D4 antagonist L-649,923 and placebo on the airway response to antigen challenge in eight men with mild asthma known to have both an early and late response to inhaled antigen. " 05/01/1987 - "The effect of an oral leukotriene D4 antagonist L-649,923 on the response to inhaled antigen in asthma." 01/01/1987 - "Effect of an oral leukotriene D4 antagonist L-649,923 on the response to inhaled antigen in asthma."
5.	Hemorrhagic Shock 03/01/1988 - "Our data suggest that peptide leukotrienes are important mediators of hemorrhagic shock and that blockade of leukotriene-induced vasoconstriction may underlie the beneficial effects of L-649,923 in hemorrhagic shock." 03/01/1988 - "We studied the effects of a novel selective peptide leukotriene antagonist, L-649,923, in a rat model of hemorrhagic shock. "

Related Drugs and Biologics

1.	Leukotrienes
2.	Leukotriene Antagonists (Leukotriene Receptor Antagonists)
3.	Leukotriene D4
4.	Antigens
5.	leukotriene D4 receptor (cysteinyl leukotriene receptor)
6.	Lipoxygenase Inhibitors
7.	4,5- Dihydro- 1- (3- (trifluoromethyl)phenyl)- 1H- pyrazol- 3- amine
8.	Thyroxine (Levothyroxine)
9.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
10.	Peptides (Polypeptides)