2-acetyl-4(5)-tetrahydroxybutylimidazole
contaminant/component of caramel coloring III; produces lymphopenia without toxic effects in rats and mice; prevents spontaneous and cyclophosphamide-induced diabetes in mice
Also Known As:
2-ATHBI; 2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole; 2-acetyl-4-tetrahydroxybutylimidazole
Networked: 8
relevant articles (0 outcomes,
0 trials/studies)
Bio-Agent Context: Research Results
Experts
Related Diseases
1. | Lymphopenia (Lymphocytopenia)
09/09/2005
- " To further define egress requirements, we addressed why treatment with the food colorant 2-acetyl-4-tetrahydroxybutylimidazole (THI) induces lymphopenia. " 01/01/1996
- " 2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole (THI) is an immunosuppressive component of caramel food colouring that causes lymphopenia in mice and rats by an unknown mechanism. " 01/01/2023
- " 2-Acetyl-4-tetrahydroxybutylimidazole (THI), a by-product of Class Ⅲ caramel color, is generally recognized to cause lymphopenia in mammals. " 01/01/1993
- " The compound 2-acetyl-4-tetrahydroxybutylimidazole (THI), a component of ammonia caramel, has been shown to cause lymphopenia and to impair several immune functions in rats and mice. " 10/01/1988
- " Accordingly, the haematological effects were studied in mice of oral administration in drinking water of 2-acetyl-4(5)-tetrahydroxybutylimidazole (THI), the component of AC responsible for lymphopenia. "
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2. | Contact Dermatitis (Eczema, Contact)
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3. | Granuloma
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4. | Experimental Arthritis
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