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maleylalbumin

Also Known As:

malBSA; maleyl-BSA; maleyl-albumin; maleylated BSA; maleylated bovine serum albumin

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Albumins: 31532
    - Serum Albumin: 9893
      - Bovine Serum Albumin: 2890
        maleylalbumin: 8
  - Blood Proteins: 12459
    - Serum Albumin: 9893
      - Bovine Serum Albumin: 2890
        maleylalbumin: 8

Experts

1.	Awati, A: 1 article (09/2002)
2.	Nieuwland, M G B: 1 article (09/2002)
3.	Parmentier, H K: 1 article (09/2002)
4.	Schrama, J W: 1 article (09/2002)
5.	Sijben, J W C: 1 article (09/2002)
6.	Basu, S K: 1 article (05/2000)
7.	Mukhopadhyay, A: 1 article (05/2000)
8.	Roy, R P: 1 article (05/2000)
9.	Srividya, S: 1 article (05/2000)

Related Diseases

1.	Neoplasms (Cancer) 02/01/1989 - "Maleyl-albumin, at concentrations producing lower affinity binding, stimulates tumor cytolysis, expression of mRNA encoding TNF, and suppression of INF-gamma-induced expression of Ia Ag. " 11/05/1982 - "An important biological consequence of protease secretion by macrophages, tumor-cytolysis, was also triggered by engagement of the receptor for maleylated bovine serum albumin. " 03/01/1995 - "Fe2+ or Cu2+ oxidized LDL inhibits release of nitric oxide when triggered by LPS and direct cytolysis of tumor cells when triggered by maleylated BSA or LPS. " 05/01/2000 - "We showed that muramyl dipeptide (MDP) conjugated to maleylated bovine serum albumin (MBSA) was internalized by macrophages (Mphi) through scavenger receptor (SCR)-mediated endocytosis, which leads to 50-fold higher cytotoxic activity against non-Mphi tumor cells compared with that elicited by free MDP-treated Mphi. "
2.	Mastocytoma 08/15/1987 - "Cytolysis of P815 mastocytoma targets was triggered by maleylated-BSA, in a dose-dependent manner, in murine peritoneal macrophages primed in vivo by BCG. "
3.	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 04/11/1994 - "A conjugate of the antineoplastic drug doxorubicin (DXR) with maleylated bovine serum albumin (MBSA) was taken up by a human histiocytic lymphoma cell line (U937) through the high efficiency process of scavenger receptor-mediated endocytosis resulting in a sixfold higher intracellular concentration of the drug compared to that obtained when the free drug was administered. "
4.	Hypersensitivity (Allergy) 09/01/2002 - "Cutaneous hypersensitivity responses to BSA and maleyl-BSA were not affected by the diet. " 09/01/2002 - "1. Effects of linoleic and linolenic acid provided via different oil sources on total antibody (Ab) titres, Ab isotypes after primary and secondary immunisation, and cutaneous hypersensitivity (CH) responses to bovine serum albumin (BSA) and maleyl-BSA, respectively, were studied in pullets fed on one of 4 diets. "
5.	Hyperplasia 12/01/1998 - "The fluorescent probe [maleylated-bovine serum albumin (mal-BSA) conjugated with Texas-red] can be selectively targeted to intimal macrophages and smooth muscle cells recruited during formation of hyperplasia via a receptor-mediated mechanism. "

Related Drugs and Biologics

1.	Scavenger Receptors (Scavenger Receptor)
2.	methylated bovine serum albumin (MBSA)
3.	alpha-Linolenic Acid (Linolenic Acid)
4.	Bovine Serum Albumin
5.	Messenger RNA (mRNA)
6.	Peptide Hydrolases (Proteases)
7.	Nitric Oxide (Nitrogen Monoxide)
8.	Fluorescent Dyes (Fluorescent Probes)
9.	Doxorubicin (Adriamycin)
10.	Antineoplastic Agents (Antineoplastics)