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rogletimide
Also Known As:
2-ethyl-2-(4-pyridyl)glutarimide; 3-PYG; 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione; pyridoglutethimide; rogletimide, (+-)-isomer
Networked:
6
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Piperidines: 17
Piperidones: 37
Glutethimide: 100
Aminoglutethimide: 502
rogletimide: 6
Related Diseases
1.
Breast Neoplasms (Breast Cancer)
10/01/1992 - "
The influence of aminoglutethimide and its analogue rogletimide on peripheral aromatisation in breast cancer.
"
11/01/1991 - "
The aromatase inhibitor, 'pyridoglutethimide' (PyG), has been shown previously to suppress serum oestrogen levels in postmenopausal breast cancer patients and to achieve clinical responses at a dose of 500 mg twice daily (b.d.).
"
01/01/1991 - "
Pharmacokinetics and pharmacodynamics of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione in patients with postmenopausal breast cancer.
"
10/01/1992 - "
The influence of the prototype aromatase inhibitor Aminoglutethimide (AG) and its analogue Rogletimide (RG) on peripheral aromatisation were investigated in 13 postmenopausal women with advanced breast cancer.
"
11/01/1991 - "
Endocrine, pharmacokinetic and clinical studies of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione ('pyridoglutethimide') in postmenopausal breast cancer patients.
"
2.
Neoplasms (Cancer)
05/15/1992 - "
The potential of the method is demonstrated by the quantitative analysis of the anti-cancer drug rogletimide in the plasma of patients after treatment.
"
11/01/1991 - "
Antitumor effect of pyridoglutethimide, an aromatase inhibitor, on 7,12-dimethylbenz(a)anthracene-induced mammary tumors of rat.
"
11/01/1991 - "
The antitumor effects of pyridoglutethimide (PG; 3-ethyl-3-(4-pyridyl) piperidine -2, 6-dione), a new analogue of aminoglutethimide (AG), were examined in rats with DMBA-induced mammary tumors.
"
3.
Leiomyoma (Uterine Fibroids)
05/01/1990 - "
Both pyridoglutethimide and aminoglutethimide inhibited the aromatase activity of uterine leiomyoma and cultured choriocarcinoma Enami cells as well as immunopurified human placental aromatase cytochrome P-450 by more than 90%, with IC50 values of 10-19 and 5-7 mumol/l, respectively.
"
4.
Choriocarcinoma
05/01/1990 - "
Both pyridoglutethimide and aminoglutethimide inhibited the aromatase activity of uterine leiomyoma and cultured choriocarcinoma Enami cells as well as immunopurified human placental aromatase cytochrome P-450 by more than 90%, with IC50 values of 10-19 and 5-7 mumol/l, respectively.
"
Related Drugs and Biologics
1.
rogletimide
2.
Aromatase Inhibitors
3.
Aminoglutethimide (Cytadren)
4.
Cytochrome P-450 Enzyme System (Cytochrome P450)
5.
Aromatase (CYP19)
6.
piperidine
Related Therapies and Procedures
1.
Aftercare (After-Treatment)