CGP 20712A
structure given in first source; CGP 26505, a beta1-selective beta-adrenoceptor antagonist, is the (S)-isomer of CGP 20712A
Also Known As:
1-(2-((3-carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazoylyl)phenoxy)-2-propanol methanesulfonate; 2-hydroxy-5-(2-(hydroxy-3-(4-((1-methyl-4-trifluoromethyl)-1H-imidazol-2-yl)phenoxy)propyl)aminoethoxy)benzamide; CGP 20712; CGP 26505; CGP-20712; CGP-20712-A; CGP-20712A; CGP-26505
Networked: 7
relevant articles (0 outcomes,
0 trials/studies)
Bio-Agent Context: Research Results
Experts
1. | Heubach, Jürgen F:
2 articles
(04/2003 - 05/2002)
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2. | Kaumann, Alberto J:
2 articles
(04/2003 - 05/2002)
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3. | Ravens, Ursula:
2 articles
(04/2003 - 05/2002)
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4. | Cooper, Samantha L:
1 article
(01/2022)
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5. | Hill, Stephen J:
1 article
(01/2022)
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6. | Pannucci, Patrizia:
1 article
(01/2022)
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7. | Woolard, Jeanette:
1 article
(01/2022)
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8. | Wragg, Edward S:
1 article
(01/2022)
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9. | Corrêa, F M A:
1 article
(12/2012)
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10. | Fortaleza, E A T:
1 article
(12/2012)
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Related Diseases
1. | Tachycardia (Tachyarrhythmias)
01/01/2022
- " CGP 20712A attenuated the BAY 60-6583-induced tachycardia. " 12/27/2012
- " Pretreatment of the MeA with the selective β(1)-adrenoceptor antagonist CGP 20712 (10, 15, and 20 nmol/100 nL) caused an opposite effect on the HR response, and a significant decrease in the restraint-evoked tachycardia was observed only after the dose of 20 nmol, without a significant effect on the BP response. " 04/01/2003
- " In TG4 right atria, however, (-)-CGP 12177-evoked tachycardia was resistant to blockade by CGP 20712A but antagonised by ICI 118,551, consistent with mediation through human beta(2)-adrenoceptors. " 05/01/2002
- " 2. Sinoatrial tachycardia, evoked by (-)-adrenaline was resistant to blockade by beta(2)-selective ICI 118,551 (50 nM) but antagonized by beta(1)-selective CGP 20712A (300 nM). "
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2. | Myocardial Ischemia (Ischemic Heart Diseases)
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3. | Infarction (Infarctions)
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4. | Heart Failure
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5. | Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
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