IC 831423

MW 1714 daltons; synthetic pentasaccharide representing minimum binding sequence of heparin to antithrombin III

Also Known As:

IC-83.1423; heparin pentasaccharide; D-Glucose, O-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranosyl-(1-4)-O-beta-D-glucopyranuronosyl-(1-4)-O-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranosyl-(1-4)-O-2-O-sulfo-alpha-L-idopyranuronosyl-(1-4)

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Glycosaminoglycans: 5640
    - Heparin: 24996
      - IC 831423: 7
  - Oligosaccharides: 3566
    - IC 831423: 7

Experts

1.	Bouças, Rodrigo I: 1 article (06/2012)
2.	Cavalheiro, Renan P: 1 article (06/2012)
3.	Fareed, Jawed: 1 article (06/2012)
4.	Hoppenstead, Debra: 1 article (06/2012)
5.	Jarrouge-Bouças, Thais R: 1 article (06/2012)
6.	Lima, Marcelo A: 1 article (06/2012)
7.	Moraes, Fabio A: 1 article (06/2012)
8.	Nader, Helena B: 1 article (06/2012)
9.	Tersariol, Ivarne L S: 1 article (06/2012)
10.	Trindade, Edvaldo S: 1 article (06/2012)

Related Diseases

1.	Thrombosis (Thrombus) 07/01/1988 - "A chemically synthesized heparin pentasaccharide (Institut Choay, Paris, France) has been shown to exhibit an antithrombotic action in a rabbit stasis induced thrombosis model, in an IV dose range of 25 to 200 micrograms/kg (0.5 to 3.5 micrograms/ml plasma circulating concentrations). " 04/15/1987 - "Antithrombotic activity of a synthetic heparin pentasaccharide in a rabbit stasis thrombosis model using different thrombogenic challenges." 07/15/1986 - "Intravenous antithrombotic activity of a synthetic heparin pentasaccharide in a human serum induced stasis thrombosis model." 03/01/2004 - "This ensures that heparin and its newer derivatives, such as heparin pentasaccharide, are the mainstay therapeutics for control of thrombosis or inappropriate clotting. "
2.	Venous Thrombosis (Deep-Vein Thrombosis) 06/01/2012 - "Notably, although of similar molecular weight as well as polymeric backbone, the synthetic heparin pentasaccharide showed significant hemorrhagic action and negligible antithrombotic activity in a venous thrombosis model, contrasting with C3, that displayed negligible hemorrhagic effect and potent antithrombotic action. "
3.	Thrombocytopenia (Thrombopenia) 07/01/1997 - "A chemically synthesized heparin pentasaccharide, which has purely anti-factor Xa activity and does not induce thrombocytopenia, is also in clinical trial. "
4.	Neoplasm Metastasis (Metastasis) 03/01/2006 - "Importantly, the superior inhibitory capacity on P-selectin function of unfractionated heparin and LMWH nadroparin as opposed to LMWH enoxaparin and synthetic heparin pentasaccharide fondaparinux strongly correlated to the inhibitory potency of each in inhibiting experimental lung metastasis in vivo. "

Related Drugs and Biologics

1.	Heparin (Liquaemin)
2.	P-Selectin
3.	Enoxaparin (Lovenox)
4.	Nadroparin (Nadroparin Calcium)
5.	Factor Xa (Coagulation Factor Xa)
6.	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)
7.	Fondaparinux (Arixtra)

Related Therapies and Procedures

1.	Therapeutics