1,5- dihydro- 7- (1- piperidinyl)- imidazo(2,1- b)quinazolin- 2(3H)- one

09/01/1993 - "KDH-8 tumor cells (10(4)) were iv inoculated on day 0, and DN-9693 was ip injected at a dose of 150 micrograms twice a day for 7 days on day 0 approximately 7. Rats were sacrificed on day 20, and same studies as above were done. "
09/01/1993 - "DN-9693 had no direct anti-tumor effects either in vivo or in vitro. "
09/01/1993 - "This platelet aggregation by KDH-8 tumor cells was inhibited by DN-9693 with dose-dependency. "
01/01/1990 - "The platelet-enhanced tumor cell attachment to the endothelium was inhibited in the presence of DN-9693. "
01/01/1990 - "Inhibitory effects of DN-9693 on platelet-enhanced tumor cell attachment to cultured endothelium."

09/01/1993 - "In this artificial pulmonary metastases, the decrease of the number of lung nodules was observed in WKA rat treated with DN-9693. "
07/01/1986 - "Spontaneous pulmonary metastasis of 3LL was also inhibited by DN-9693. "
07/01/1986 - "Effects of DN-9693, a new metastasis inhibitor, on murine hematogenous metastasis."
01/01/1990 - "These data suggest that the inhibitory effects of DN-9693 on metastasis are in part mediated by the prevention of tumor cell attachment to the vascular endothelium."
07/01/1986 - "Continuous administration of DN-9693 during and after surgical excision of the primary tumors was the most effective treatment against the development of pulmonary metastases of 3LL."

07/01/1986 - "1-3 microM of DN-9693 completely inhibited platelet aggregation induced by B16 melanoma subline BL6 and Lewis lung carcinoma (3LL) cells. "

09/01/1991 - "A new cyclic adenosine monophosphate phosphodiesterase inhibitor, DN-9693, was examined to see whether myocardial reperfusion injury could be reduced in a setting of cardioplegic arrest through its antiaggregation effect on leukocytes. "
09/01/1991 - "Effect of a cyclic adenosine monophosphate phosphodiesterase inhibitor, DN-9693, on myocardial reperfusion injury."

07/01/1986 - "Either intravenous or oral administration of DN-9693 (1-10 mg/kg) sufficiently suppressed thrombus formation and subsequent pulmonary metastasis caused by intravenously inoculated BL6 or 3LL cells. "