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11888CERM

structure given in first source; a quaternary ammonium analog of bepridil

Also Known As:

CERM 11888; CERM-11888

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - Bepridil: 280
      - 11888CERM: 3

Related Diseases

1.	Contracture 06/05/1992 - "The lack of effect of the quaternary derivative of bepridil CERM 11888 indicated that intracellular sites of action may be involved in the activity of bepridil on veratrine-induced contracture. " 09/01/1989 - "2. Bepridil diminished the amplitude of contracture in a concentration-dependent fashion, and this effect was significantly different from that of CERM 11888 which, like verapamil, only reduced the amplitude at the highest concentration used. " 09/01/1989 - "Comparative effects of bepridil, its quaternary derivative CERM 11888 and verapamil on caffeine-induced contracture in ferret hearts." 09/01/1989 - "1. The effects of bepridil, its quaternary derivative: CERM 11888 (methyl-pyrrolidinium bromide) (10(-7)-10(-5) M), and verapamil (10(-7)-10(-6) M) were compared on caffeine-induced contracture of isolated ventricular trabeculae of the ferret. "
2.	Bradycardia 12/01/1989 - "2. The four drugs caused a bradycardia with the following order of potency: bepridil greater than CERM 11888 greater than diltiazem greater than verapamil. "

Related Drugs and Biologics

1.	Bepridil (Vascor)
2.	Verapamil (Calan)
3.	Veratrine
4.	Diltiazem (Cardizem)
5.	Caffeine (No Doz)
6.	Bromides