fasudil (AT 877)

11/15/2005 - "Treatment with fasudil within 48 h of acute ischemic stroke onset significantly improved the patient's clinical outcome. "
09/01/2000 - "Fasudil may be beneficial in the treatment of acute ischemic stroke."
01/12/2007 - "The present findings indicate that the RKI fasudil reduces ischemic neuronal damage with a wide therapeutic time window in gerbil, and may be useful in the treatment of acute ischemic stroke in humans."
06/01/2013 - "Pharmacological inhibition of the EphA4 signaling cascade using two ROCK inhibitors,Y-27632 and fasudil, improved motor function of mice after stroke. "
11/15/2005 - "Further evaluations, for example, 3-month functional outcomes in a larger clinical trial, may help to define the efficacy of fasudil in acute ischemic stroke."

01/01/2014 - "Effects of fasudil on hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats."
02/20/2004 - "The fasudil treatment improved pulmonary hypertension, right ventricular hypertrophy, and pulmonary vascular lesions with suppression of VSMC proliferation and macrophage infiltration, enhanced VSMC apoptosis, and amelioration of endothelial dysfunction and VSMC hypercontraction. "
08/01/2015 - "Intravenous fasudil improves in-hospital mortality of patients with right heart failure in severe pulmonary hypertension."
01/01/2015 - "Fasudil may partly prevent and reverse the development of pulmonary hypertension and right ventricular hypertrophy and myocardial cell injury."
01/01/2015 - "Effect of fasudil on hypoxic pulmonary hypertension and right ventricular hypertrophy in rats."

08/01/2011 - "The data suggest that fasudil hydrochloride hydrate ameliorates myocardial fibrosis in rats with type 2 diabetes at least in part through inhibiting the JNK and TGFβ/Smad pathways. "
12/01/2015 - "The present study assessed the inhibitory effect of fasudil, a ROCK inhibitor using immunohistochemistry, reverse transcription-quantitative polymerase chain reaction and western blot analyses, in vivo and in vitro, to elucidate the mechanisms underlying renal interstitial fibrosis. "
02/01/2014 - "Effects of fasudil on the portal and systemic hemodynamics of patients with cirrhosis."
01/01/2013 - "However, fasudil's effects on renal fibrosis in DN remain unknown. "
08/01/2012 - "The cardiac hypertrophic level, apoptotic pathway and fibrosis signaling were further inhibited in the fasudil-treated group. "

11/15/2005 - "Several small, non-placebo-controlled trials suggest that fasudil reduces myocardial ischemia in patients with stable or vasospastic angina. "
01/01/2003 - "In contrast, 11 of the 13 patients pretreated with fasudil had no evidence of myocardial ischemia during the second infusion of ACh (p < 0.01). "
09/01/2004 - "Fasudil successfully resolved the spasm and improved myocardial ischemia in all patients without any systemic adverse effects. "
01/01/2005 - "Emerging clinical data have shown that oral fasudil 80 mg three times daily is effective in preventing myocardial ischemia in patients with stable angina pectoris. "
04/02/2002 - "Fasudil was effective in preventing ACh-induced coronary artery spasm and resultant myocardial ischemia in patients with vasospastic angina. "

11/01/2012 - "Inhibition of this pathway using fasudil resulted in a significant reduction of proteinuria in treated S rats (compared with untreated S). "
05/01/2012 - "Fasudil treatment significantly improved survival and decreased proteinuria, particularly when treatment was started at 18 weeks. "
06/01/2013 - "These results indicate that fasudil with OL reduces proteinuria by protecting podocyte integrity and alters the interstitial macrophage density/phenotype, thereby exerting renoprotective effects against CKD."
02/01/2011 - "Late intervention with fasudil reduced glomerulosclerosis, but did not influence proteinuria. "
03/01/2007 - "The treatment with high-dose fasudil ameliorated proteinuria, glomerulosclerosis, renal interstitial fibrosis, and macrophage infiltration in OLETF rats. "